可溶性髓样细胞触发受体1在感染性疾病中的研究应用进展

The Research Progress of Soluble Myeloid Cells Triggering Receptor-1 in Infectious Diseases

髓样细胞触发受体1(TREM-1)是近年来发现在炎性反应中起重要作用的细胞膜受体,选择性地表达在中性粒细胞、成熟单核细胞和巨噬等细胞的表面,可溶性髓样细胞触发受体1(sTREM-1)是TREM-1剪切变异体,在炎性反应中TREM-1与sTREM-1的配体结合,阻断TREM-1介导的信息传导路径,下调炎性反应,是机体自我调节保护机制。研究发现,sTREM-1与脓毒症和肺部感染等疾病关系密切,在血清、支气管肺泡灌洗液中sTREM-1水平检测在临床上的应用研究取得较大进展,对感染性疾病的诊断和预后判断有较大的价值。

Triggering receptor expressed on myeloid cells-1 （ TREM-1 ） is a cell membrane receptor playing an important role in inflammatory response found in recent years, which is selectively expressed on the surface of myeloid cells such as ueutrophil, mature monocyte and macrophages. Soluble triggering receptor expressed on myeloid cells-1 （ sTREM-1 ） is the splice variant of TREM-1. In the inflammatory response, sTREM-1 combines with the ligands of TREM-1, and blocks the signal transduction pathway mediated by TREM-1, thus down-regulates inflammation response, which is a self-regulating protection mechanism of the body. In recent years,studies have found that sTREM-1 is closely related to the diseases such as sepsis and lung infection. The testing of sTREM-1 level in serum and bronchoalveolar lavage fluid, has made great progress in the clinical applications, which has shown a considerable value on the diagnosis and prognosis judgment of infectious diseases.