白细胞介素33水平与非小细胞肺癌相关性研究

The Research on Correlation of Interleukin-33 and Non-small Cell Lung Cancer

目的检测非小细胞肺癌（NSCLC）患者血清中白细胞介素33（IL-33）的变化,探讨两者是否具有相关性。方法选取2012年1月至2013年3月于张家口市第四医院进行诊治的49例NSCLC患者作为NSCLC组,同时选取50例健康献血者作为健康对照组,应用酶联免疫吸附试验法检测血清中IL-33水平,并进行统计学分析。结果 NSCLC患者血清中的IL-33 364（178~537）ng/L,显著高于健康对照组的156（52~193）ng/L（P〈0.05）,且肿瘤恶性程度越高,IL-33水平升高越明显,两者呈正相关（r=0.31,P〈0.05）;不同病理类型患者间IL-33水平的差异无统计学意义（P〉0.05）。结论 NSCLC患者血清中IL-33水平高于健康对照者,且与肿瘤分期呈正相关,可作为评估疾病恶性分期的潜在指标,为临床治疗提供一定的理论依据。

Objective To test the serum interleukin-33 （IL-33） level in non-small cell lung cancer patients（ NSCLC）, and to explore the correlation of IL-33 and NSCLC. Methods Altogether 49 NSCLC patients and 50 healthy volunteers in Zhangjiakou Fourth Hospital from Jan. 2012 to Mar. 2013 were collected as research objects, serum IL-33 level were detected by ELISA, and statistically analyzed. Results IL-33 levels were higher in NSCLC patients[364（178-537）pg/ml] than healthy volunteers[ 156（52-193）pg/ml, P 〈0.05 ], and the higher of the malignant degree, the higher the IL-33 levels, with a positive correlation （r =0.31 ,P 〈 0.05 ）; IL-33 levels between patients with different pathological types had no statistical difference （ P 〉 0.05 ）. Conclusion IL-33 levels are higher in NSCLC patients than the healthy volunteers, and were positively associated with tumor stage. Serum IL-33 can be used to evaluate the rlaalignancy degree of NSCLC, and provide clinical basis for disease treatment.