泛昔洛韦联合生殖器疱疹疱液自体接种治疗生殖器疱疹的临床疗效分析

Analysis of clinical efficacy of famciclovir combined with genital herpes blister fluid auto-inoculation in the treatment of genital herpes

目的 :探讨泛昔洛韦联合生殖器疱疹疱液自体接种治疗生殖器疱疹的临床疗效。方法 :将我院收治的86例生殖器疱疹患者随机分为试验组和对照组,对试验组患者给予泛昔洛韦联合生殖器疱疹疱液自体接种治疗,对对照组患者仅给予泛昔洛韦治疗,比较两治疗组患者的临床疗效、至临床症状改善的时间和不良反应的发生情况。结果 :试验组患者的治愈率为83.72%、总有效率为100.00%,均显著高于对照组(分别为39.53%和93.02%,P均<0.05);试验组患者的复发率为16.28%,显著低于对照组的60.47%(P<0.05);试验组患者的至皮损愈合平均时间、自觉疼痛和瘙痒平均持续时间也均显著短于对照组(P均<0.05)。试验组中有2例患者发生轻度的乏力和发热,但这些不良反应均在2 d内自行消失;对照组中未见明显不良反应发生。结论 :泛昔洛韦联合生殖器疱疹疱液自体接种治疗能够显著提高生殖器疱疹的治疗效果、降低复发率,具有临床应用价值。

Objective： To explore the clinical efficacy of the autologous vaccination of genital herpes blister fluid in the treatment of genital herpes. Methods： Eighty-six cases of patients with genital herpes were randomly divided into an experimental group and a control group, in which famciclovir combined with the autologous vaccination of genital herpes blister lfuid were given in the experimental group while only famciclovir in the control group. Clinical efifcacy, time for the appearance of the improvement of clinical symptoms and incidence of adverse reaction were compared between two groups. Results：The rates of the cure and the total effectiveness were 83.72%and 100%in the experimental group, which were signiifcantly higher than those in the control group （39.53%and 93.02%, P〈0.05）;the recurrence rate was 16.28%in the experiment group, which was signiifcantly lower than that in the control group （60.47%, P〈0.05）;the average times for the healing of skin damage and the conscious pain and itching were signiifcantly shorter in the experiment group than in the control group （P〈0.05）. Two cases of mild weakness and fever occurred in the experimental group, which could disappear within two days, however, such adverse reactions could not be observed in the control group. Conclusion： Famciclovir combined with the autologous vaccination of genital herpes blister fluid can significantly improve the treatment effect of genital herpes, reduce the recurrence rate and possesses a value of clinical application.