2型糖尿病合并冠心病与幽门螺杆菌感染的相关性研究

Correlation between Helicobacter pylori infection and type 2 diabetes mellitus complicated with coronary heart disease

目的 探讨2型糖尿病（T2DM）合并冠心病（CHD）与幽门螺杆菌（Hp）感染的相关性.方法 选择临床确诊的住院和门诊T2DM患者185例,分为T2DM非合并CHD组（单纯T2DM组,109例）和T2DM合并CHD组（T2DM＋CHD组,76例）,检测血脂、血清Hp-IgG抗体、高敏C-反应蛋白（hs-CRP）、同型半胱氨酸（HCY）水平,进行统计学对比分析.结果 185例T2DM患者中,91例（49.19％） Hp-IgG抗体（＋）显著高于对照组（30.00％）（P＜0.01）,T2DM＋CHD组（64.47％）显著高于单纯T2DM组（38.53％） （P＜ 0.01）;Hp感染组合并CHD者（53.85％）显著高于Hp非感染组（28.72％）（P＜0.01）.T2DM合并CHD与Hp感染具有显著相关性（r=0.195,t=2.690,P＜0.01）.Hp感染组血清TG、TC、LDL-C、HCY和hs-CRP水平均显著高于Hp非感染组（P＜0.01）,血清HDL-C水平显著低于Hp非感染组（P＜0.01）.结论 T2DM合并CHD与Hp感染具有相关性,可能通过影响血脂代谢、炎性反应及HCY水平促进CHD发生发展,清除或预防Hp感染可能是防治T2DM合并CHD的策略之一.

Objective To explore the correlation between Helicobacter pylori infection and type 2 diabetes mellitus （T2DM） complicated with coronary heart disease （CHD）.Methods 185 patients diagnosed with type 2 diabetes,including inpatients and outpatients,were chosen and then divided into a T2DM group （109 cases with only T2DM） and a mixed group （76 cases with T2DM complicated with CHD）.The levels of blood lipid,serum Hp-IgG antibody,High-sensitive C-reactive protein （hs-CRP）,and homocysteine （HCY） in all patients were detected.The data were statistically analyzed.Results Among the 185 patients with T2DM,91（49.19%） got Hp-IgG antibody（＋）,which was significantly higher than the control group （30.00%） （P 〈 0.01）.More patients got Hp-IgG antibody（＋） in the mixed group than in the T2DM group（64.47% vs.38.53%,P 〈 0.01）.More patients infected by Hp complicated with CHD than patients not infected by Hp （53.85% vs.28.72%,P 〈 0.01）.T2DM complicated with CHD positively correlated with Hp infection（r=0.195,t=2.690,P 〈 0.01）.The serum levels of TC,TG,LDL-C,HCY,and hs-CRP were markedly higher and the serum level of HDL-C was obviously lower in the patients with than without Hp infection （P 〈 0.01）.Conclusions T2DM complicated with CHD correlates with Helicobacter pylori infection.It may accelerate the generation and development of CHD affecting blood lipid metabolism,inflammatory reaction,and HCY level.Therefore,removing or preventing Hp infection might prevent and cure T2DM with CHD.