4-(5-芳基-1,3,4-噻二唑-2-基硫代)-2-三氟甲基噻吩并[2,3-d]嘧啶的合成

Synthesis of 4-( 5-Aryl-1,3,4-thiadiazol-2-ylthio)-2-( trifluoromethyl) thieno [2,3-d] pyrimidines

以5-芳基-1,3,4-噻二唑-2-硫醇与2-三氟甲基-4-氯噻吩并[2,3-d]嘧啶发生亲核取代反应,合成出四种结构新颖的含噻二唑环噻吩并[2,3-d]嘧啶类含氟衍生物,用红外光谱、核磁共振氢谱和元素分析方法进行了表征.

Four new fluorinated thieno[2,3-d]pyrimidine derivatives containing 1,3,4-thiadiazole were synthesized by the nucleophilic substitution reaction of 4-chloro-2-trifluoromethylthieno [ 2,3-d] pyrimi-dine with 5-aryl-1,3,4-thiadiazol-2-thiols.The structure of these new compounds was confirmed by IR,1 H NMR and elemental analysis .