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窖蛋白与心血管系统疾病关系的研究进展 被引量：3

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摘要 胞膜窖(Caveolae)是细胞膜上的特异性囊状小凹结构,在维持细胞正常功能及信号传递方面有着重要的作用,其主要由醇类、鞘磷脂及蛋白质组成。窖蛋白(Caveolin)是Caveolae的重要结构蛋白和标记蛋白,通过脚手架区域将特异性信号受体募集在Caveolae上,将胞外信号分子转移到细胞内。其参与的细胞过程有小泡运输、胆固醇平衡、信号转导、抑制肿瘤等。目前已发现的Caveolin家族成员有3类,Cav-1,Cav-2,Cav-3,这三类蛋白质在心血管系统广泛存在。细胞类型特异性研究表明Caveolae蛋白主要存在于内皮细胞、平滑肌细胞成纤维细胞和心肌细胞。Caveolin的变化与心血管疾病之间有着密切的关系。
作者 李静静 赵建力
机构地区 山西医科大学 山西医科大学第一医院
出处 《中西医结合心脑血管病杂志》 2014年第9期1124-1126,共3页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金 国家自然科学基金(No.81270185)
关键词 动脉粥样硬化 心肌肥大 缺血/再灌注损伤 窖蛋白
分类号 R54 [医药卫生—心血管疾病] R256.2 [医药卫生—中医内科学]
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参考文献42

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共引文献3

同被引文献91

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中西医结合心脑血管病杂志
2014年 第9期

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