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帕金森病冻结步态研究进展 被引量：11

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摘要 冻结步态是帕金森病患者临床表现中常见且最具有致残性的病理步态，多发生于疾病的中晚期，易导致跌倒、外伤、抑郁，严重影响患者的生活质量和社会功能[1]。我们就帕金森病冻结步态的研究进展作一综述。一、帕金森病冻结步态冻结步态被定义为“企图行走时或前进过程中步伐短暂、突然地中止或明显减少[2]，主要表现为运动的短暂性阻滞，步态常呈非对称性，单侧下肢偶发起始，
作者 李利 刘晶 罗蔚锋 刘春风
机构地区 苏州大学附属第二医院神经内科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2014年第8期565-567,共3页 Chinese Journal of Neurology
基金 江苏省自然科学基金项目（BK2010229）
关键词 冻结步态 帕金森病 临床表现 社会功能 生活质量 主要表现 非对称性 致残性
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献25

  • 1Josiah AF, Gruber-Baldini AL, Anderson KE, et al. The effects of gait impairment with and without freezing of gait in Parkinson' s disease[J]. Parkinsonism Relat Disord, 2012, 18: 239-242.
  • 2Nutt JG, Bloem BR, Giladi N, et al. Freezing of gait: moving forward on a mysterious clinical phenomenon [ J ]. Lancet Neurol, 2011, 10: 734-744.
  • 3Schaafsma JD, Balash Y, Gurevich T, eta!. Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson' s disease[J]. Eur J Neurol, 2003, 10: 391-398.
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二级参考文献23

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共引文献8

同被引文献102

  • 1马烈,孙斌.依达拉奉治疗血管源性帕金森综合征的疗效观察[J].中国全科医学,2008,11(19):1794-1795. 被引量：19
  • 2王海燕,那万秋.雌激素替代疗法及心理干预结合艾司西酞普兰治疗围绝经期抑郁症的疗效[J].中国老年学杂志,2014,34(9):2363-2365. 被引量：23
  • 3张朝辉,张亚林.躯体形式障碍临床研究进展[J].临床心身疾病杂志,2006,12(6):469-471. 被引量：39
  • 4王冰.依达拉奉治疗血管性帕金森综合征的疗效观察[J].中国实用神经疾病杂志,2007,10(9):45-46. 被引量：10
  • 5Lazzarini M, Martin S, Mitkovski M, et al. Doxyeyeline restrains glia and confers neuroproteetion in a 6-OHDA Parkinson model [J]. Glia, 2013, 61: 1084-1100.
  • 6Byler SL, Boehm GW, Karp JD, et al. Systemic lipopolysaccha- ride plus MPTP as a model of dopamine loss and gait instability in C57B1/6J mice [J]. Behav Brain Res, 2009, 198 (2) : 434 - 439.
  • 7Goralski KB, Renton KW. Brain inflammation enhances 1-meth- yl-4-phenylpyridinium-evoked neurotoxicity in rats [ J]. Toxicol Appl Pharmacol, 2004, 196:381 - 389.
  • 8Anitua E, Pascual C, P6rez-Gonzalez R, et al. Intranasal PRGF- Endoret enhances neuronal survival and attenuates NF-KB-de- pendent inflammation process in a mouse model of Parkinson's disease [J]. J Controlled Release, 2015, 203 : 170 - 180.
  • 9Hu Y, Yu SY, Zuo LJ, et al. Parkinson disease with REM sleep behavior disorder features, α-synuclein, and inflammation [ J]. Neurology, 2015, 84(9): 888-894.
  • 10Del Trediei K, Jost WH. [ Gastrointestinal dysfunction in idio- pathic Parkinson "s disease ] [ J ]. Der Nervenarzt, 2012, 83 (10) : 1282 -1291.

引证文献11

二级引证文献63

中华神经科杂志
2014年 第8期

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