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微小RNA介导的RNA激活的研究进展 被引量：2

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摘要 miRNA是一类长度为21 ～24个核苷酸的非编码小分子RNA.miRNA分布于各种生物中,在各物种间具有高度进化保守性、基因表达时序性和组织特异性,是一组不编码蛋白的短序列RNA.以往研究认为miRNA对靶基因的调控是在转录后水平上,通过对靶基因转录体剪切或对其翻译抑制两种机制来下调靶基因的表达,
作者 李羚 邢朝凤 周国平
机构地区 南京医科大学附属无锡市人民医院儿童医院呼吸科
出处 《中华医学杂志》 CAS CSCD 北大核心 2014年第30期2395-2397,共3页 National Medical Journal of China
关键词 微小RNA MIRNA 激活 介导 编码蛋白 RNA分布 组织特异性 靶基因
分类号 R3416 [医药卫生—基础医学]
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参考文献28

  • 1Lagos-Quintana M, Rauhut R, Lendeckel W, et al. Identification of novel genes coding for small expressed RNAs [ J ]. Science, 2001,294:853-858.
  • 2Lau NC, Lira LP, Weinstein EG, et al. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans [ J]. Science,2001,294:858-862.
  • 3Ambros V. The functions of animal microRNAs [ J ]. Nature, 2004,431:350-355.
  • 4McManus MT, Petersen CP, Haines BB, et al. Gene silencing using micm-RNA designed hairpins [ J ]. RNA,2002,8 : 842-850.
  • 5Mourelatos Z, Dostie J, Paushkin S,et al. miRNPS: a novel class of ribonucleoproteins containing nuerous micmRNAs [ J ]. Genes Dev, 2002,16:720 -728.
  • 6Li LC, Okino ST, Zhao H, et al. Small dsRNAs induce transcriptional activation in human ceils [ J ]. Proc Nat/Acad Sci U S A,2006 , 103 : 17337-17342.
  • 7Janowski BA, Younger ST, Hardy DB, et al. Activating gene expression in mammalian cells with promoter-targeted duplex RNAs [J]. Nat Chem Biol,2007,3:166-173.
  • 8Britten RJ, Davidson EH. Gene regulation for higher cells: a theory[J]. Science,1969, 165:349-357.
  • 9Chen Z, Place RF, Jia ZJ, et al. Antitumor effect of dsRNA- induced p21 (WAF1/CIP1) gene activation in human bladder cancer cells[J]. Mol Cancer Ther,2008 ,7 :698-703.
  • 10Yang K, Zheng XY, Qin J, et al. Up-regullation of p21 WAF1/ Cipl by saRNA induces Gl-phase arrest and apoptosis in 3"24 human bladder cancer cells[J]. Cancer Lett,2008 ,265 :206-214.

同被引文献18

  • 1罗桂芬,陈继兰,文杰,赵桂苹,郑麦青,孙世铎.鸡A-FABP基因多态性分析及其与脂肪性状的相关研究[J].遗传,2006,28(1):39-42. 被引量：54
  • 2Wang C, Chen Z, Ge Q, et al. Up-regulation of p21 (WAFI/ CIP 1 ) by miRNAs and its implications in bladder cancer cells [J]. FEBS Lett, 2014, 588(,24) :4654-4664. DOI: 10. 1016/j. febslet. 2014.10,037.
  • 3Huang V, Qin Y, Wang J, et al. RNAa is eonserved in mammalian cells[J]. PLoS One, 2010, 5( 1 ) : e8848. DOI: 10. 1371/journal. pone. 0008848.
  • 4Place RF, I,i LC, Pookot D, el al. MieroRNA-373 induces expression of genes with complementary promoter sequences [ J ]. Proc Natl Aead Sci U S A, 2008, 105(5) :1608-1613. DOI:10. 1073/pnas. 0707594105.
  • 5Zhang H, Sun X, Hao D. Upregulalion of micrnRNA-370 facilitates the repair of amputated fingers through targeting forkhead box protein Ol [ J ]. Exp Biol Med ( Maywood ) , 2015 Aug 27. [ Epub ahead of print ]. DOI: I0. 1177/ 1535370215600549.
  • 6Obaya A.J, Kotenko 1, Cole MD, et al. The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27 (Kipl) to facilitate the activation of Cdk4/6 and early G ( 1 ) phase progression [ J ]. J Biol Chem, 2002, 277 ( 34 ) : 31263- 31269. DOI:10. 1074/jbc. M202528200.
  • 7Starostina NG, Kipreus ET. Multiple degradation pathways regulate versatile C1P/KIP CDK inhibitors [ J ]. Trends Cell Biol, 2012, 22( ! ) :33-41. DOI:10. 1016/j: tcb. 2011.10. 004.
  • 8Behnsawy HM, Miyake H, Abdalla MA, et al. Expression of cell cycle-associated proteins in non-muscle-invasive bladder cancer: correlation with intravesical recurrence following transurethral resection[ J ]. Urol Oneol, 2011, 29 ( 5 ) : 495-501.
  • 9Tang K, Wang C, Chert Z, et al. Clinicopathologic and prognostic significance of p21 ( Cipl/Wafl ) expression in bladder cancer[J]. lnt .1 Clin Exp Pathol, 2015, 8(5) :4999-5007.
  • 10张军,董飚,张红,储冬生,徐国庆,龚道清,段修军,赵旭庭,顾志良.鸭A-FABP基因的克隆及其组织表达[J].畜牧兽医学报,2008,39(6):819-822. 被引量：19

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中华医学杂志
2014年 第30期

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