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突触囊泡蛋白2A:抗癫痫药物的新靶点 被引量:7

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摘要 突触囊泡蛋白2A(SV2A)是新型抗癫痫药物左乙拉西坦的作用位点,它参与调节神经递质的释放和囊泡循环进而维持着突触囊泡的正常功能。SV2A敲除小鼠表现出癫痫易感性的增高。不同癫痫模型以及癫痫患者脑组织标本SV2A的表达变化提示其可能参与了癫痫发生。
作者 武晨 江文
出处 《国际神经病学神经外科学杂志》 2014年第3期260-264,共5页 Journal of International Neurology and Neurosurgery
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