卡培他滨单药连用3周方案治疗老年晚期消化道肿瘤疗效评价

Study the Capecitabine 3 Weeks a Laparoscope, Usually Connected to a Single drug for Treatment of Elderly advanced Digestive tract Tumor

目的：研究卡培他滨单药连用3周治疗老年晚期消化道肿瘤的临床效果。方法：选取我院2012年10月～2013年10月收治的老年晚期消化道肿瘤患者64例，经患者及家属同意，分成对照组和常规组，每组各32例。对照组采用卡培他滨2000 mg/m2/d，2次服用，连用3周（21天），4周重复的用药方法；常规组采用卡培他滨2500mg/m2/d，2次服用，连用2周（14天），3周重复的用药方法。用药2个周期后评价临床疗效、不良反应。结果：对照组的有效率为34．4％（11/32），临床获益率为75．0％（24/32）；常规组的有效率为31．2％（10/32），临床获益率为71．9％（23/32），2组比较，P＞0．05，差异无统计学意义。对照组不良反应（恶心呕吐，手足综合征，口腔炎，腹泻）的发生率明显低于常规组，且多为Ⅰ～Ⅱ度。常规组不良反应发生率高，而且多数是Ⅲ～Ⅳ度。结论：卡培他滨单药减量并延长用药时间为3周的方案治疗老年晚期消化道肿瘤疗效好，并且不良反应较少，值得临床应用。

Objective：To study the capecitabine 3 weeks a laparoscope , usually connected to a single drug for treatment of elderly ad-vanced digestive tract tumor .Methods：From October 2012 to October 2012 treated 64 cases of elderly patients with late digestive tract tumor, with the consent of the patient and family , were divided into control group and normal group , 32 cases in each group.Result s：the effective rate was 34.4%（11/32） in the control group, the clinical benefit rate was 75.0%（24/32）;Normal group, the effective rate was 31.2%（10/32）, the clinical benefit rate was 71.9 %（23/32）, compared two groups, P 〉0.05, there was no statistically signifi-cant difference .Conclusion：Capecitabine single reduction and prolong the use time of 3 weeks of good curative effect on senile late diges-tive tract tumor , and less adverse reactions , worthy of clinical application.