表皮生长因子受体在慢性外阴营养不良中的表达

Exploration of the Epidermal Growth Factor Receptor and the Relationship between Chronic vulvar dystrophy

目的：本文旨在探讨表皮生长因子受体EGFR和慢性外阴营养不良的关系。方法：取慢性外阴营养不良患者病变区皮肤60例和正常对照组皮肤组织55例，通过免疫组化方法，检测表皮生长因子受体在两者中的阳性表达情况，对比其表达的差异。结果：慢性外阴营养不良者阳性27例，占32．7％，对照组7例阳性表达，占12．73％，经统计学处理慢性外阴营养不良者阳性表达率明显高于正常对照组皮肤组织（ P＜0．01）。结论：慢性外阴营养不良患者皮肤存在着上皮细胞增值和分化异常，具有上皮代谢活跃的特征。

Objective：The purpose of this paper is to explore the epidermal growth factor receptor and the relationship between chro-nic vulvar dystrophy.Methods：Chronic vulvar dystrophy patients disease damage of heavy area of the skin and normal control group in skin tissue, by immunohistochemical method ,chronic vulvar dystrophy patients disease damage of heavy area of 60 cases of skin and skin in 55 cases, normal control group by immunohistochemical method , detection of epidermal growth factor receptor positive expres-sion in different organizations, contrast the differences expressed in different tissues. Results：Malnutrition in chronic vulvar positive 27 cases, accounted for 32 .7%, control group （ 12 .73%） , 7 cases of positive expression of chronic vulvar dystrophy after statistics pro-cessing the positive expression rate is significantly higher than normal control group in skin tissue （P 〈0.01）.Conclusion：Chronic vulvar dystrophy sufferers there exists abnormal epithelial cell proliferation and differentiation of skin , has the characteristics of epithelial metabolism active.