摘要
碘代谢相关基因是甲状腺癌分化的重要标志.在某些机制作用下,DTC失去或下调碘代谢相关基因的表达,发生失分化现象,导致癌细胞丧失对131Ⅰ的摄取能力.此类患者预后较差.明确DTC失分化机制,有助于对失分化患者的治疗.笔者从131Ⅰ辐射损伤、基因突变、相关肿瘤标志物及蛋白质等多方面,对DTC失分化现象的产生机制予以综述.
131 ^I-metabolizing genes are markers for differentiation of thyroid carcinoma.The loss or down-regulation of these genes represents progression of dedifferentiation,which results in low 131 I uptake and suggests a poor prognosis.The mechanism of dedifferentiation of DTC is important for treatment.This article reviews the mechanism of dedifferentiation from 131^Ⅰ radiation damage,gene mutation,tumor markers and protein.
出处
《中华核医学与分子影像杂志》
CSCD
北大核心
2014年第4期327-330,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
