摘要
目的:探讨MRI动态增强扫描定量参数对脑胶质瘤病理分级的诊断价值。方法:经手术病理证实的脑胶质瘤患者19例,其中高级别胶质瘤(HGG)12例,低级别胶质瘤(LGG)7例。所有患者均行常规MRI平扫及MRI动态增强(DCE)扫描。利用北京大学前沿交叉学科研究院开发的Ktrans计算系统,分别测量颅内占位性病变实质区及瘤周水肿区的Ktrans值和Ve值。不同级别胶质瘤Ktrans值的比较采用Mann-Whitney U检验。采用受试者工作特征曲线(ROC)对Ktrans和Ve值进行分析。结果:HGG及LGG组的Ktrans值分别为(0.24±0.17)和(0.07±0.04)min-1,差异有统计学意义(t=2.625,P=0.018);Ve分别为0.92±0.15和0.50±0.25,差异有统计学意义(t=4.613,P<0.001);Ktrans以0.12min-1为阈值,诊断敏感度为83%,特异度为86%;Ve以0.88为阈值,敏感度为83%,特异度为85%。结论:采用Ktrans值结合常规MRI序列,对于胶质瘤的分级诊断具有一定的临床应用价值。
Objective：To evaluate the value of dynamic enhanced MR scanning with transfer coefficient （Ktrans） in the diagnosis of histopathology grading of cerebral glioma. Methods： Nineteen patients with pathology confirmed cerebral glioma （high-grade glioma, HGG, n =12 ; low-grade glioma, LGG, n=7） underwent plain and dynamic contrast-enhanced MR scanning. Peking University First Hospital medical ethical committees approved the study. Ktrans system developed by Peking University was used to measured the Ktrans and Ve of intra-cerebral space occupying lesion and peri-tumoral edema respectively. Mann-Whitney U test was used to compared the Ktrans value of glioma with different pathology grading. Re- ceiver operating characteristic curve （ROC） were performed for the analysis of Ktrans and Ve values. Results：The Ktrans values of HGG and LGG were （0.24±0.17） and （0.07±0.04）rain-1 respectively,with significant statistic difference （t=2. 625 ,P=0. 018）. The Ve of HGG and LGG was 0. 92 ± 0. 15 and 0.50± 0. 25 respectively, with significant statistical difference （t=2. 625,P〈0. 001）. Using 0.12 as cut-off value of Ktrans for differentiating LGG from HGG,the sensitivity was 83 %, and specificity was 86 %. With 0.88 as the cutoff value of Ve, the sensitivity was 83 %, specificity was 85 %. Con- clusion：Ktrans value in combination with routine MR scanning is helpful in the pathology grading of cerebral glioma, with clinical significance.
出处
《放射学实践》
2014年第8期893-895,共3页
Radiologic Practice
