老年慢性心力衰竭血清标志物TNF-α和MMP-9的检测及对预后判断的价值

Clinical value of TNF-α and MMP-9 concentration in elderly patients with chronic heart failure

目的:观察老年慢性心力衰竭(CHF)血清标志物肿瘤坏死因子-α(TNF-α)和基质金属蛋白酶(MMP-9)的表达及对预后判断的价值。方法:将我院收治的97例老年CHF患者作为观察组,选择同期体检的30例健康者作为对照组,观察两组患者TNF-α、MMP-9及白细胞介素(IL)-6等血清表达水平,同时观察心力衰竭(心衰)严重程度及患者预后情况,并分析其相关性。结果:观察组TNF-α、MMP-9及IL-6等血清表达水平显著高于对照组(P<0.05);观察组患者心功能等级与TNF-α、MMP-9及IL-6等血清表达水平呈显著正相关(P<0.05),与预后改善程度也呈显著正相关(P<0.05)。结论:CHF血清标志物TNF-α和MMP-9的表达水平与心功能等级及预后显著相关,对于判断病情及预后有重要的临床价值。

Objective：To observe prognosis significance of TNF-α and MMP-9 concentration in elderly patients with chronic heart failure （CHF）. Method：A tatal of 97 cases of elderly patients with CHF as observation group, 30 cases of healthy people as control group. The serum TNF-α, MMP-9 and IL-6 levels were observed, the corre- lation between TNF-α, MMP-9 and IL-6 levels and cardiac function were analyzed. Result： The TNF-α, MMP-9 and IL-6 concentrations in observation group were significantly higher than those in control group （P〈0.05）. The levels of TNF-α and MMP-9 were positively correlated with the patienfs heart function （P〈0.05）, as well as pos- itively correlated with the patient＇s prognosis （P〈0.05）. Conclusion：The level of TNF-α and MMP-9 play an important role in the development of CHF, which will be helpful for the prediction of condition and prognosis.