摘要
脑钠肽也称B型利钠肽,其合成及分泌主要在心室,刺激BNP基因表达及分泌增高的因素主要为物理机械牵张,即心房和心室肌细胞感受压力和容量负荷后分泌[1]。先天性心脏病(先心病)患儿心脏彩超测量结果因受心脏结构、心内分流、瓣膜反流等因素影响,左室射血分数(LVEF)、左室短轴缩短(LVFS)有时很难准确反映心功能。本研究通过分析先心病并心力衰竭(心衰)患儿血清N末端B型脑钠肽(NT-proBNP)水平的改变及其与病情严重程度、与LVEF及LVFS的关系,探讨血清NT-proBNP水平在先心病合并心衰的临床诊断及心功能评估中的价值。
This study was designed to observe the change of the serum amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with congenital heart disease (CHD) and heart failure (HF), and ana- lyzed the value of the NT-proBNP in cardiac function assessment in these patients. The results showed that serum NT-proBNP levels were significantly increased in turn in CHD+ HF groups that divided into cardiac function I , Ⅱ , Ⅲ, Ⅳ levels (P〈0.05). And the serum NT-proBNP levels in CHD+HF groups were significantly higher than those in healthy control group (P〈0.01). Furthermore, the serum NT-proBNP levels in CHD+ HF groups were negatively correlated with LVEF and LVFS (r=- 0. 563, -0. 227,P〈0.05).
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2014年第8期736-737,共2页
Journal of Clinical Cardiology
关键词
先天性心脏病
心力衰竭
血清氨基末端脑钠肽
congenital heart disease
heart failure
serum amino-terminal pro-brain natriuretic peptide