合并糖尿病的冠心病患者冠状动脉病变程度与血清内皮祖细胞CD34^+的相关性

Correlation between coronary lesion severity and peripheral blood cell CD34^+ ratio in the coronary heart disease patients complicating diabetes mellitus

内皮祖细胞（EPCs）是一种能分化为血管内皮细胞的前体细胞,研究发现循环血中的EPCs具有参与损伤内皮的修复和缺血组织血管新生的能力,有助于损伤血管的再内皮化进程[1-2]。本研究以CD34＋作为EPCs表面标志,以分析合并糖尿病的冠心病患者冠状动脉（冠脉）病变程度与CD34^＋之间的关系及其临床意义。

To investigate the correlation between coronary lesion severity and peripheral blood cell CD34^＋ ra- tio in the CHD patients with DM. The ratios of the CD34^＋ cells in the CHD patients （group A, n=61） were sig- nificantly lower than that the non-CHD patients＇ （group B, n=35） （P〈0.01）. While the ratios of CHD patients with DM （group A1, n=29） was significantly lower than non-DM CHD patients＇ （group A2, n= 32） （P〈0.05）. The CD34^＋ ratio and the Gensini score was negatively correlated with group A1 （r=-0. 552, P〈0.01）. The CD34^＋ ratio decreased more significantly while the coronary lesions severity.