临床医用1.5T磁共振对AD模型大鼠的颅脑MR成像研究

To Investigate the Brain MRI Imaging of Model Rats with Alzheimer's Disease by Using 1.5 T Clinical Medical

目的使用临床医用1.5TMR成像仪对阿尔茨海默病(Alzheimer Disease,AD)大鼠模型的颅脑行MR成像研究。材料和方法随机选择健康雌性SD大鼠10只(7-8周),通过多影响因素建立SD大鼠的AD模型,然后使用临床医用1.5TMR成像仪对AD模型大鼠进行T1WI、T2WI、T2*WI、SWI成像。结果 AD模型大鼠大脑的颞顶叶皮质、腹侧海马下皮质区和海马区可以发现一些散在的类圆形的低信号区,并与脑实质Aβ免疫组化、Thioflavine S及铁染色阳性结果相重叠。结论在未有超高场小动物专用磁共振成像仪的情况下,临床医用磁共振对AD模型大鼠颅脑MR成像的研究是可行的。

Objective The 1.5T MR imager was used to investigate the MRI imaging of model rats＇ brain which with Alzheimer＇s disease.Methods Ten female SD rats, aged 7-8 weeks,were selected randomly. Then induced Alzheimer＇s disease model basing on multi-effects factors. Finally, the MRI sequences of T1WI、T2WI、T2＊WI and SWI were scanned by using 1.5T MR imager.Results Some round hypointensity focus can be detected in the cortex and hippocampus of the AD model rat brain,which appeared a overlap with the positive results of βimmunohistochemical staining、Thioflavin S staining and iron staining.Conclusion When the high field MRI imager which can be offered for animals exclusively are in the scarce case, the brain MR imaging of rat model with clinical medical 1.5T MR imager is feasible.