血液透析患者血液钙结合蛋白S100A12的影响因素及其与动脉硬化关系的研究

The influence factors of S100A12 and its correlation with carotid artery atherosclerosis in hemodialysis patients

目的探讨血液透析患者血液钙结合蛋白S100A12(简称S100A12)水平及其影响因素,研究其与颈动脉粥样硬化之间的关系。方法检测150例血液透析患者血常规(白细胞总数)、肝功能[包括丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、白蛋白(Alb)]、肾功能[包括血肌酐(Cr)、尿素(Urea)]、血脂[包括甘油三酯(TG)、总胆固醇(TC)]、血糖、糖化血红蛋白和S100A12浓度,以100名健康体检者作为正常对照组,采用高分辨二维超声技术测量颈动脉内膜中层厚度(CIMT)。采用Person相关分析S100A12与CIMT的相关性,采用多因素逐步回归分析血浆S100A12浓度的影响因素。结果血液透析组血浆S100A12浓度明显高于正常对照组(P<0.05);CIMT与血浆S100A12浓度呈正相关(r=0.4,P<0.01)。多因素逐步回归分析显示高白细胞总数、低TC和低Alb是影响血浆S100A12浓度的因素。结论 S100A12与血液透析患者的动脉粥样硬化有关。白细胞总数、TC和Alb能影响血液S100A12浓度。

Objective To investigate the influence factors of plasma S100 calcium binding protein A12( S100A12) level in hemodialysis patients and the correlation between S100A12 and carotid artery atherosclerosis.Methods A total of 150 hemodialysis patients and 100 healthy subjects were enrolled. The white blood cell counts,alanine transaminase( ALT),aspartate aminotransferase( AST),albumin( Alb),creatinine( Cr),urea,triglyceride( TG),total cholesterol( TC),blood glucose,glycosylated hemoglobin and S100A12 concentrations of hemodialysis patients were determined and compared with those of healthy subjects. Carotid intima-media thickness( CIMT) was measured by high-resolution B-mode ultrasonography in hemodialysis patients and also compared with that in healthy subjects. The correlation between S100A12 and CIMT was analyzed by Person correlation analysis. The multivariate regression analysis was used to analyze the influence factors of S100A12 concentration. Results The plasma S100A12 concentration was higher in hemodialysis patients than in healthy subjects( P < 0. 05). Significant positive correlation was recorded between S100A12 and CIMT( r = 0. 4,P < 0. 01). Multivariate regression analysis identified high white blood cell counts as a positive plasma independent determinant and low TC and low Alb as negative independent determinants of plasma S100A12 concentration. Conclusions S100A12 is related to carotid artery atherosclerosis. The white blood cell counts,TC and Alb are associated with S100A12 concentration.