代谢综合征及其风险因子对血清前列腺特异性抗原水平的影响

The influence of metabolic syndrome and its risk components on serum prostate-specific antigen level

目的了解代谢综合征及其风险因子对血清前列腺特异性抗原(PSA)水平的影响。方法选取3家医院体验中心40岁以上无前列腺癌病史、符合标准且资料完整的男性健康体检者5 717名,行体格检查并测定相关的生化指标[甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和空腹血糖(FBG)]和PSA,以中华医学会糖尿病学分会(CDS)2007年标准定义代谢综合征及其风险因子,统计分析代谢综合征及其风险因子对血清PSA水平的影响。结果 5 717名健康体检者年龄为(53.49±10.64)岁,代谢综合征患者占27.1%,PSA为(1.04±0.72)ng/mL。代谢综合征组与非代谢综合征组间PSA水平差异无统计学意义(P>0.05)。在控制年龄的偏相关性分析中,体重指数(BMI)、FBG与PSA水平呈负相关[相关系数(r)分别为-0.05和-0.03,P<0.05];代谢综合征及其它风险因子与PSA无相关性(P>0.05)。在校正年龄的协方差分析中,按BMI和FBG水平分组,随着BMI或FPG水平的增加,校正年龄后的对数PSA值逐渐降低。结论代谢风险因子中超重和高血糖与血清PSA水平呈负相关。在临床解释PSA水平时,应考虑BMI和血糖水平对PSA水平的影响。

Objective To investigate the influence of metabolic syndrome and its risk components on serum prostate-specific antigen( PSA) level. Methods A total of 5 717 male healthy subjects over 40 years old without the history of prostate cancer,who met the requirements and had integrated data,were enrolled from 3 hospitals. Physical examination and laboratory tests [triglyceride( TG),high-density lipoprotein cholesterol( HDL-C),fasting blood glucose( FBG) and PSA]were performed. According to Chinese Diabetes Society criteria for metabolic syndrome and its risk components,the influence of metabolic syndrome and its risk components on serum PSA level was analyzed statistically. Results The mean age of 5 717 healthy subjects was( 53. 49 ± 10. 64) years old,the prevalence of metabolic syndrome was 27. 1%,and the PSA was( 1. 04 ± 0. 72) ng /mL. The PSA levels between metabolic syndrome group and healthy control group were not significantly statistical( P > 0. 05). After adjusting for age,the partial correlation among body mass index( BMI),FBG and PSA levels was negative,and the correlation coefficients( r) were- 0. 05 and- 0. 03,respectively( P < 0. 05). There was no correlation between metabolic syndrome and its risk components with serum PSA( P > 0. 05). For analysis of covariance,the age-adjusted means of serum PSA levels by BMI and FBG were cmputed,and they decreased with the increase of BMI and FBG. Conclusions The correlation of serum PSA level with BMI and FBG is negative. The influence of BMI and FBG on PSA level should be considered.