血清维生素D3、可溶性髓系细胞触发受体1水平对老年肺炎诊断价值

Significance of serum vitamin D3 and soluble myeloid cell trigger receptor 1 level for the diagnosis of senile pneumonia

目的通过检测老年肺炎患者血清可溶性髓系细胞触发受体1(sTREM-1)、维生素D3(VitD3)水平,探讨sTREM-1、VitD3与老年肺炎的关系,为临床诊断与治疗提供依据。方法选取63例老年肺炎患者为病例组,健康者30名作为对照组。用酶联免疫吸附试验(ELISA)检测sTREM-1、电化学发光法检测血清VitD3水平,并进行组间比较。结果老年肺炎组血清sTREM-1水平[234.80±68.90)pg/mL]明显高于对照组[(74.20±41.20)pg/mL],差异有统计学意义(P<0.01);老年肺炎组血清VitD3水平[(18.92±7.27)pg/mL]明显低于对照组[(33.75±9.28)pg/mL],差异有统计学意义(P<0.05);sTREM-1的受试者工作特征(ROC)曲线下面积为0.916,VitD3的ROC曲线下面积为0.897。结论 sTREM-1、VitD3是肺炎诊断的良好指标,对老年肺炎诊断有一定的帮助。

Objective Through the detections of serum soluble myeloid cell trigger receptor 1( sTREM-1) and vitamin D3( VitD3) levels in senile pneumonia patients,to investigate the relations of sTREM-1 and VitD3 with senile pneumonia,and to provide the reference for clinical diagnosis and treatment. Methods A total of 63 patients with senile pneumonia were enrolled,and 30 healthy subjects were enrolled as control group. sTREM-1 was determined by enzyme-linked immunosorbent assay( ELISA),and electrochemiluminescence was used to determine serum level of VitD3. The results were analyzed comparatively between the 2 groups. Results The sTREM-1 in senile pneumonia group [( 234. 80 ± 68. 90) pg /mL]was significantly higher than that in control group[( 74. 20 ± 41. 20) pg /mL] with statistical significance( P < 0. 01). VitD3 level in senile pneumonia group [( 18. 92 ± 7. 27) pg /mL] was significantly lower than that in control group[( 33. 75 ± 9. 28) pg /mL] with statistical significance( P < 0. 05). The areas under receiver operating characteristic( ROC) curve were 0. 916 for sTREM-1 and 0. 897 for VitD3. Conclusions VitD3 and sTREM-1 are good indicators for the diagnosis of senile pneumonia.