尿酸转运体与帕金森病研究进展

Research advances in the association of urate transporters and Parkinson's disease

尿酸是生理性的抗氧化剂,流行病学及临床资料显示低尿酸水平与帕金森病(PD)发病率增高密切相关,PD患者的血尿酸水平显著降低,高血尿酸水平能够降低PD的发病以及减慢PD的进展速度。尿酸转运体在尿酸分泌和重吸收过程中发挥关键作用,从而影响尿酸水平。本文将从尿酸转运体的角度介绍尿酸转运体与PD的研究进展。

Uric acid is a kind of physiological antioxidants. The epidemiology and clinical studies indicate that its lower level is closely related to the higher incidence of Parkinson＇s Disease（PD）. The serum urate concentrations of PD patients are much lower. Lower incidence and better prognosis have been observed on PD patients with higher serum urate. Urate transporters affect urate secretion and reabsorption, which have a strong and apparent impact on urate concentrations. This review discusses current information on the characteristics of urate transporters, with specific focus on their association with PD.