药物化学实验合成美沙拉嗪的方法改进

The improvement synthesis methods of mesalazine in pharmaceutical chemistry experiments

目的探讨药物化学实验合成美沙拉嗪的改进方法。方法通过改进实验方法,以水杨酸为原料,控制硝酸硝化反应,在酸性条件下以锌粉和铁粉混合交替添加的办法进行硝基还原。结果第一步反应得到5-硝基水杨酸收率为65%,美沙拉嗪的总收率为39%。结论改进后的合成方法简单,实验结果可靠,便于学生学习和掌握,可提高教学效果和质量。

Objective To study the improvement synthesis methods of mesalazine in pharmaceutical chemistry experiments.MethodsUsing salicylic acid as raw material, improving the methods by controlling the nitration reaction, zinc powder and iron powder with 5-nitro salicylic acid were added alternately under acid condition to reduce nitro group to amino group. ResultsThe 5-nitro salicylic acid yield was 65% in the first step, and the total yield of mesalazine was 39%.ConclusionThe improved synthesis method is simple and the results is reliable, which can facilitate students to learn and master, and improve the teaching effect and quality.