低血钾型周期性麻痹41例临床分析

Clinical analysis of 41 patients with hypokalemic periodic paralysis

目的分析低血钾型周期性麻痹(HypoPP)的临床特点。方法回顾性分析41例低血钾型周期性麻痹患者的临床资料。结果在41例患者中,原发性28例,继发性13例,其中继发于甲亢11例,原发性醛固酮增多症2例;HypoPP主要表现为四肢弛缓性肌无力,大多有诱发因素,男性多发;发作时血钾低于正常,部分患者可出现肌酸激酶升高,未见发生恶性心律失常及呼吸肌麻痹。结论 HypoPP以肌无力伴低钾血症为其临床特点,早期诊断及时补钾治疗预后较好,对继发性HypoPP患者应强调病因治疗。

ObjectiveTo investigate the clinical features of hypokalemic periodic paralysis （HypoPP） .Methods The clinical data of 41 patients with HypoPP were retrospectively studied and summarized.ResultsIn 41 cases, idiopathic 28 cases, secondary13 cases. 11 were secondary from hyperthyroidism, 2 were primary aldosteronism. The main clinical features of HypoPP were sluggish myoasthenia of four limbs, Most patients had obvious incentives, It had a predilection in young men. Serum potassium levels of all patients were lower than the normal range and creatine kinase levers of some patients were higher than the normal, No patients experienced respiratoryparalysis and malignant arrhythmia when disease onset.Conclusion HypoPP is a disorder characterized by myoasthenia accompanied by lowered serum potassium levels, patients with early diagnosis and replenishment of potassium in time had good prognosis. Etilogical treatment should be underlined for secondary cases.