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长链非编码RNA与细胞多向分化 被引量：5

Long Non-coding RNA and Cell Differentiation
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摘要 本文重点概述LncRNA参与细胞分化的相关机制,列举了LncRNA在不同细胞系中参与调控的各种作用方式,如LncRNA参与维持胚胎干细胞多潜能状态、胚胎干细胞分化、神经细胞分化、肌肉分化、表皮细胞分化、成骨细胞分化、脂肪生成的机制等. In this paper, we reviewed the diverse mechanisms that long non-coding RNA （LncRNA） regulated cell differentiation via several representative differentiation systems, such as the mechanism that LncRNA maintains the pluripotent state of embryonic stem ceils and regulates stem cells differentiation, neural cell differentiation, muscle differentiation, epidermal differentiation, osteoblast differentiation and adipogenesis.
作者 卢旱云 左长清 吴铁
机构地区 广东医学院药理教研室
出处 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2014年第8期746-751,共6页 Chinese Journal of Biochemistry and Molecular Biology
基金 国家自然科学基金项目(No.81101357) 东莞市高等院校科研机构科技项目(No.2011108102029)~~
关键词 长链非编码RNA 细胞分化 机制 long non-coding RNA cell differentiation mechanism
分类号 Q75 [生物学—分子生物学]
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参考文献47

  • 1Costa F F. Non-coding RNAs: Meet thy masters[J]. Bioessays, 2010, 32 (7):599-608.
  • 2Ponting C P, Oliver P L, Reik W. Evolution and functions of long noncoding RNAs[J]. Cell, 2009, 136 (4):629-641.
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同被引文献83

  • 1王康岩,凌英会,章孝荣.长链非编码RNA与动物的基因表达调控[J].畜牧兽医学报,2015,46(4):509-517. 被引量：4
  • 2余梅,毛华明,黄必志.牛肉品质的评定指标及影响牛肉品质的因素[J].中国畜牧兽医,2007,34(2):33-35. 被引量：79
  • 3FATICA A,BOZZONI I. Long non-coding RNAs :new players in cell differentiation and development [ J ]. Nat Rev Genet, 2014,15:7-21.
  • 4ZHANG J, CUI X, SHEN Y, et al. Distinct expression pro- files of LncRNAs between brown adipose tissue and skele- tal muscle [ J ]. Biochem Biophys Res Commun, 2014,443 (3) : 1028-1034.
  • 5PONTING C P, OLIVER P L, REIK W. Evolution and functions of long noncoding RNAs [ J ]. Cell, 2009, 136 (4) :629-641.
  • 6DEY B K, MUELLER A C, DUTTA A. Long non-coding RNAs as emerging regulators of differentiation, develop- ment, and disease [ J ]. Transcription, 2014, 5 ( 4 ) e944014, doi : 10.4161/21541272. 2014. 944014.
  • 7GUTI'MAN M, DONAGHEY J, CAREY B W, et al. lincR- NAs act in the circuitry controlling pluripotency and dif- ferentiation [ J ]. Nature,2011,477 (7364) : 295-300.
  • 8ZUO C, WANG Z, LU H, et al. Expression profiling of ln- cRNAs in C3 H10 T1/2 mesenchymal stem cells undergo- ing early osteoblast differentiation [ J ]. Mol Med Rep, 2013,8(2) :463-467.
  • 9SUN L, GOFF L A,TRAPNELL C, et al. Long noncoding RNAs regulate adipogenesis [ J ]. Proc Natl Acad Sei, 2013,110(9) :3387-3392.
  • 10NEGUEMBOR M V, JOTHI M, GABELLINI D. Long non-coding RNAs, emerging players in muscle differentiation and disease[ J]. Skelet Muscle,2014,4( 1 ) :8.

引证文献5

二级引证文献14

中国生物化学与分子生物学报
2014年 第8期

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