期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

干扰素α对人免疫缺陷病毒潜伏库的影响

Progress on the effects of alpha interferon on HIV-1 reservoirs
原文传递
导出
摘要 艾滋病已成为全球性的公共卫生问题。因为HIV-1潜伏库的存在，HAART虽然延缓了疾病的进程，减少了相关机会性感染的发生，但是却无法将病毒从人体内完全清除。近年来IFN-α对HIV-1潜伏库的清除受到广泛关注，此文对IFN—α对HIV-1病毒潜伏库的作用进行综述。 AIDS has become a global public health issue in recent years. Because of the existence of HIV-1 reservoirs, although HAART can slow down the progress of the disease and reduce related opportunistic infections, it cannot eliminate the virus completely. In recent years, many researchers have found that IFN-α may remove HIV-1 reservoirs. The article reviews the progress on the elimination of HIV-1 by IFN-α.
作者 翁文佳 高艳青 吴昊 李威 焦艳梅
机构地区 首都医科大学附属北京佑安医院皮肤与性病科
出处 《国际流行病学传染病学杂志》 CAS 2014年第4期269-272,共4页 International Journal of Epidemiology and Infectious Disease
关键词 干扰素Α HIV-1潜伏库 Interferon-alpha HIV- 1 reservoirs
分类号 R512.91 [医药卫生—内科学]
  • 相关文献

参考文献30

  • 1Siliciano JD, Kajdas J, Finzi D, et al. Longterm follow-up studies confirm the stability of the latent reservoir for HIV -1 in resting CD41' cells[J].Nat Med,2003,9:727-728.
  • 2Le T, Farrar J, Shikuma C. Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implication for eradication[J]. AIDS,2011,25:871- 872.
  • 3Pope M, Haase AT. Transmission, acute HIV-l infection, and the quest for strategies to prevent infection[J]. Nat Med, 2003, 9: 847- 852.
  • 4Williams SA, Greene WC. Regulation of HIV-l latency by T-cell activation[J]. Cytokine, 2007, 39: 63-74.
  • 5Mok HP, Lever A. Waking up the sleepers: HIV latency and reactivation[J]. J Formos Med Assoc, 2008, 107:909-914.
  • 6Zhang H. Reversal of HIV-l latency with anti-microRNA inhibitors [J]. Int J Biochem CeliBiol, 2009,41: 451-454.
  • 7Felice B, Cattoglio C, Cittaro D, et al. Transcription factor binding sites are genetic determinants of retroviral integration in the human genome[J/OL]. PLoS One, 2009, 4: e4571.http://dx.plos.orgl 1O.13711journal.pone. 0004571.
  • 8Ciuffi A. Mechanisms governing lentivirus integration site selection [J]. Curr Gene Ther, 2008, 8: 419-429.
  • 9Kanzaki LI, Ornelas SS, Argalaraz ER. RNA interference and HIV- 1 infection[J]. Rev Med Virol, 2008, 18: 5-18.
  • 10Willey RL, Byrum R, Piatak M, et al. Control of viremia and prevention of simian-human immunodeficiency virus-induced disease in rhesusmacaques immunized with recombinant vaccinia viruses plus inactivated simian immunodeficiency virus and human immunodeficiency virus type 1 particles[J]. J Virol, 2003, 77: 1163- 1174.

二级参考文献23

  • 1Zheng Zhang~1 Fu-Sheng Wang~(1,2) ~1Research Center of Biological Therapy,Beijing 302 Hospital,Beijing 100039,China,~2Research Centre of Biological Therapy,Beijing Institute of Infectious Diseases,Beijing 302 Hospital,100 Xi Si Huan Middle Road,Beijing 100039,China..Plasmacytoid Dendritic Cells Act as the Most Competent Cell Type in Linking Antiviral Innate and Adaptive Immune Responses[J].Cellular & Molecular Immunology,2005,2(6):411-417. 被引量：16
  • 2Perelson AS et al. Nature,1997;387:188-191
  • 3Natarajan V et al. Lancet,1999;353:119-120
  • 4Ho DD et al. Nat Med,2000;6(7):736-743
  • 5Ho DD et al. Nature,1995;373:123-126
  • 6Volberding PA et al. AIDS Review/1997/1998,NewYork: MARCEL DEKKER, INC, 1998: 50
  • 7Siliciano RF et al. AIDS, 1999 ; 13(Suppl A) :S49-S58
  • 8Gandi RT et al.J Exp Med,1998;187:1113-1122
  • 9Yang OO et al. J Virol,1996;70:5799-5806
  • 10Pierson T et al. Ann Rev Immunol,2000;18:665-708

共引文献6

国际流行病学传染病学杂志
2014年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部