甲状腺自身抗体抗原表位的应用研究进展

Research on application development of thyroid autoantibody epitope

甲状腺自身抗体主要包括抗甲状腺球蛋白、抗甲状腺过氧化物酶及抗促甲状腺素受体的自身抗体,长期以来被当作自身免疫性甲状腺病的血清学标志。近年来的研究显示甲状腺自身抗体抗原表位可影响其功能。对于甲状腺自身抗体抗原表位及功能的研究,有助于获得其功能性分子,用于自身抗体的检测,未来更有望用于AITD、甲状腺癌等疾病的诊断、治疗,以及对疾病预后的预测。

Thyroid autoantibodies mainly including anti-thyroglobulin, anti-thyroid peroxidase, and Anti-thyroid stimulatinghormone （TSH） receptor antibodies, have been taken as serological markers of autoimmune thyroid disease for a long time. Studies inrecent years have shown that epitopes of thyroid autoantibody can affect its function. Research on these epitopes and their functions canhelp obtain functional molecules, which can be used to detect the autoantibodies. In the future they are even expected to be used for thediagnosis and treatment of AITD, thyroid cancer and other diseases, as well as the prediction of the prognosis.