梅毒螺旋体免疫相关膜蛋白的研究进展

Advances inimmune related membrane protein of Treponema pallidum

梅毒是一种由梅毒螺旋体(Treponema.pallidum,Tp)感染所引起的慢性性传播疾病。近年来,其发病率居高不下,引起了全社会广泛的关注。随着分子生物技术的发展和人们的不断探究发现,膜蛋白可能在Tp致病过程中与宿主黏附、宿主免疫炎症反应等方面起着非常重要的作用,可能为Tp的主要致病因子。因此,对Tp膜蛋白的研究是认识其对宿主的致病性和进行致病机制研究的关键,就Tp的几种主要免疫相关膜蛋白的研究进展作了简要综述。

Syphilis is a chronic sexually transmitted disease, which has arisen widespread concern in recent years, because of its high incidence rate. Treponema. pallidum （Tp） membrane proteins are thought to play an important role in Tp patho- genic processes such as host adhesion, host immune inflammatory reaction, along with the development of molecular biotechnology and progress in research. Thus, they may be as a main causative factor from Tp. Therefore, research on Tp membrane protein is cruicial to understanding its pathogenicity to host and pathogenic mechanism of syphilis. The review at- tempts to describe advances of some important immune related membrane proteins of Tp.