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解读Look AHEAD研究：生活方式干预对超重或肥胖的2型糖尿病患者还有用吗？ 被引量：2

Understanding to Look AHEAD trial ： Is intensive lifestyle intervention useful for overweight or obese patients with type 2 diabetes？
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摘要 糖尿病患者健康行动（Action for Health in Diabetes，LookAHEAD）研究显示，在超重或肥胖的成人2型糖尿病患者中．以减轻体重为主要目标的强化生活方式干预并不能降低心血管事件的发生率，但可改善心血管危险因素的控制水平，减轻肥胖相关合并症，提高患者的生活质量。 Action for Health in Diabetes（ Look AHEAD） trial showed that an intensive hlestyle intervention focusing on weight loss did riot reduce the rate of cardiovascular events in overweight or obese adult patients with type 2 diabetes. However, the intensive lifestyle intervention improved the control levels of the risk factors for cardiovascular disease, attenuated the obesity-associated comorbidities, and improved the quality of life in these patients.
作者 洪天配
机构地区 大学第三医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2014年第8期635-638,共4页 Chinese Journal of Endocrinology and Metabolism
关键词 生活方式干预 糖尿病 2型 体重减轻 心血管风险 Intensive lifestyle intervention Diabetes mellitus, type 2 Weight loss Cardiovascular risks （ Chin J Endocrinol Metab, 2014, 30 ： 635-638 ）
分类号 R587.1 [医药卫生—内分泌]
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参考文献21

  • 1Centers for Disease Control and Prevention. 2011 National Diabetes Fact Sheet [ EB/OL ]. http://www, cdc. gov/diabetes/pubs/ factsheetl 1. htm.
  • 2Xu Y, Wang L, He J, et al. Prevalence and control of diabetes in Chinese adults[J]. JAMA, 2013,310:948-959.
  • 3Buse JB~ Ginsberg HN, Bakris GL, et al. Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association[J]. Diabetes Care, 2007,30:162-172.
  • 4Harrington M, Gibson S, Cottrell RC. A review and meta-analysis of the effect of weight loss on all-cause mortality risk [ J ]. Nutr Res Rev, 2009,22:93-108.
  • 5Pan XR, Li GW, Hu YH, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study[ J]. Diabetes Care, 1997,20:537-544.
  • 6Lindstr~m J, Ilanne-Parikka P, Pehonen M, et al. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention : follow-up of the Finnish Diabetes Prevention Study[ J]. Lancet, 2006,368:1673- 1679.
  • 7Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin [ J]. N Engl J Med, 2002,346:393-403.
  • 8Wing RR, Bolin P, Brancati FL, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes [ J ]. N Engl J Med, 2013,369:145-154.
  • 9Li G, Zhang P, Wang J, et al. Cardiovascular mortality, all-cause mortality, and diabetes incidence after lifestyle intervention for people with impaired glucose tolerance in the Da Qing Diabetes Prevention Study: a 23-year follow-up study [ J ]. Lancet Diabetes Endocrinol, 2014,2:474-480.
  • 10Schellenberg ES, Dryden DM, Vandermeer B, et al. Lifestyle interventions for patients with and at risk for type 2 diabetes: a systematic review and meta-analysis [ J ]. Ann Intern Med, 2013,159 : 543-551.

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中华内分泌代谢杂志
2014年 第8期

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