构建Graves病动物模型的研究进展

Research progress in building animal model of Graves＇ disease

构建Graves病动物模型有助于对Graves病的病因、发病机制及治疗方式进行研究，经过十几年的探索和改进，Graves病模型的制备方法有很大发展。尽管目前有关Graves病动物模型构建的报导很多，作为一种比较成熟的技术，使用表达促甲状腺激素受体（TSHR）-A亚单位的腺病毒免疫小鼠，Graves病的发病率较高且相对稳定，是近几年采用较多的方法。

The establishment animal model of Graves＇ disease contributes to the study of etiology, pathogenesis and therapeutic modalities. After decades studies and making improvements, the method of building mice model of Graves＇ disease has achieved a great development. Although there were many reports of animal model building in Graves＇ disease, as a mature technology A-subunit of thyrotropin receptor （ TSHR ） -expressing adenovirus was used to establish Graves＇ disease mice model, which has been accepted widely because of its high efficacy.