肥胖及瘦素水平对偏头痛患者的影响

Effects of obesity and leptin level on migraineurs

目的探讨肥胖及血清瘦素水平对偏头痛患者的影响。方法收集52例偏头痛患者的临床资料,并与52名健康人(正常对照组)进行比较。根据肥胖状况将偏头痛患者分为全身型肥胖(TBO)亚组,非TBO亚组及腹型肥胖(ABd-O)亚组、非ABd-O亚组。采用放射免疫法测定患者的血清瘦素水平,并进行比较。结果与非TBO亚组比较,TBO亚组患者偏头痛的发作频率增多,持续时间延长,疼痛程度重(均P<0.05)。与非ABd-O亚组比较,ABd-O亚组患者偏头痛的发作频率增多,持续时间延长,疼痛程度重(均P<0.05)。偏头痛组血清瘦素水平与正常对照组的差异无统计学意义。TBO亚组与非TBO亚组的血清瘦素水平差异无统计学意义。ABd-O亚组血清瘦素水平显著高于非ABd-O亚组(P<0.05)。多因素Logistic回归分析显示,瘦素及ABd-O对偏头痛发作频率、疼痛程度及持续时间的影响无统计学意义;TBO与偏头痛的发作频率及疼痛程度有显著关系(均P<0.05),而与持续时间无关。结论 TBO对偏头痛的发作频率及疼痛程度有影响,血清瘦素水平对偏头痛无明显影响。

Objective To investigated the effects of obesity and leptin level on migraineurs. Methods The clinical data of 52 migraineurs were collected, and compared with 52 healthy people （normal control group ）. According to obesity, migraineurs group was divided into total body obesity （TBO） subgroup, non-TBO subgroup and abdominal obesity （ABd-O） subgroup, non-ABd-O subgroup. Leptin levels were determined by radioimmunoassay, the results were compared. Results Compared with non-TBO subgroup, headache attack frequency and headache duration in TBO subgroup were significantly increased, pain severity in TBO subgroup was significantly worse （ all P 〈 0. 05 ）. Compared with non-ABd-O subgroup, headache attack frequency and headache duration in ABd-O subgroup were significantly increased, pain severity in ABd-O subgroup was significantly worse （all P 〈 0. 05 ）. There was no significant difference of leptin levels between migraineurs group and normal control group. There was no significant difference of leptin levels between TBO and non-TBO subgroups. The level of leptin in ABd-O subgroup was significantly higher than that in non-ABd-O subgroup （ P 〈 0. 05 ）. Multivariate Logistic regression analysis showed neither leptin nor ABd-O had effects on the attack frequency, severity and duration of migraine; TBO was significantly correlated with the attack frequency and severity of migraine （ all P 〈 0. 05 ）, and not correlated with headache duration. Conclusions TBO has effects on the attack frequency and severity of migraine. Serum level of leptin has no significant effect on migraineurs.