PI3K/AKT通路在非小细胞肺癌顺铂耐药中的作用

Effect of PI3K/AKT Pathway on Cisplatin Resistance in Non-small Cell Lung Cancer

研究表明,PI3K/AKT信号通路在非小细胞肺癌存在异常激活,对肿瘤细胞的增殖、凋亡、存活、耐药等起着重要的作用。顺铂是临床最常用一线化疗药物,但随着治疗的进展肿瘤对其耐药的现象越来越普遍,严重制约其临床效果。顺铂耐药是多种机制共同参与的复杂过程,其中PI3K/AKT通路或其组分持续被激活是非常重要的因素之一。本文对二者关系研究领域的进展作一综述。

Accumulating evidences indicate that aberrant activation of PI3K/AKT pathway in non-small cell lung cancer plays a vital role in tumor cell proliferation,apoptosis,and survival including drug resistance.Cisplatin as first-line chemotherapy are in widespread clinical use in patients with non-small cell lung cancer,however,the development of cisplatin resistance significantly impedes its clinic efficacy.Cisplatin resistance is a complicated process that various mechanisms participating in to interact,of which PI3K/AKT pathway keeping sustained activated is one of the most important reasons.This article reviewed the progress of research on the relationship between PI3K/AKT pathway and cisplatin resistance.