借助脑功能成像技术从心脑相关入手探讨针刺治疗心绞痛的中枢机制

Using Functional Brain Imaging Technique to Study Central Mechanism of Acupuncture Therapy for Chronic Stable Angina Pectoris in View of Heart-brain Correlation

心脑相关是中医藏象理论的重要组成部分,对于现代临床仍具有指导意义。现代研究表明脑心轴、中枢自主神经网络系统与心血管疾病明确相关,并且针刺对脑心轴,如脑功能网络的连接度、自主神经功能、心率变异性、心脏功能等均具有广泛调整作用。因此,以脑功能成像技术作为研究桥梁,联合临床客观数据和主观指标,以心脑相关为切入点,可望从神经学角度客观、系统、整体地阐释针刺治疗心绞痛的中枢机制。但是其具体的神经生物化学机制仍需借助其它技术手段进行探讨。

Heart-brain correlation is an important component of Chinese medicine about the theory of zang-fu organs, which is still valuable for acupuncture clinical practice. Nowadays, increasing evidence supports the close association between the heart-brain axis, central autonomic nerve network and cardiovascular diseases, as well as the extensive regulative effects of acupuncture intervention on the heart-brain axis, functional connectivity of the brain, automatic nerve activities and cardiac functions. Therefore, the authors of the present paper hold that from the viewpoint of the heart-brain relationship, and by combining non-invasive functional brain imaging techniques with the patients＇ subjective and objective clinical indexes, our researchers will possibly and systematically reveal the underlying central mechanisms of acupuncture therapy in the treatment of chronic stable angina pectoris. However, the concrete biochemical mechanism should be proved via other advanced biological techniques.