巨噬细胞在血吸虫感染中的作用

Role of Macrophages in Schistosome Infection

血吸虫在人体中的各阶段均可致病,其在人体内释放的致病因子,可诱发宿主免疫应答,引起一系列的免疫病理变化,是造成宿主损害而导致血吸虫病的重要原因。巨噬细胞作为机体固有免疫的重要组成细胞,与血吸虫病的发生发展密切相关,本文从巨噬细胞的激活和分化,它在血吸虫病引起的免疫病理反应中的作用,及其在血吸虫免疫逃避中的作用3个方面进行了归纳和总结。

Each stage of schistosome in human body can cause disease. Pathogenic factors released by the parasites induce host immune responses and cause a series of immunopathological changes. As a major cell population in innate immunity, macrophages are important in the initiation and development of schistosomiasis. This paper summarizes the activation and polarization of macrophages, and the role of macrophages in schistosome immunopathology and immune evasion.