辅助生殖治疗中染色体多态性对妊娠结局的影响

Effects of chromosome polymorphism on pregnancy outcome of assistant reproductive treatment

目的探讨染色体多态性对辅助生殖治疗后妊娠结局的影响。方法对接受辅助生殖治疗的5 345对不孕不育夫妇进行外周血染色体检测,对其中3 435个周期的助孕过程进行回顾性分析。将发现有染色体多态的患者作为研究对象,并按不同类型分组后与染色体正常群体对照,观察受精率、卵裂率,有效胚胎形成率,累计妊娠率和早期流产率。结果总多态性组、Y染色体变异组、1/9/16号变异组、D/G组变异与正常组比较,受精率、卵裂率、有效胚胎形成率、累计妊娠率和早期流产率均无统计学差异(P>0.05);9号染色体臂间倒位的卵裂率与正常组比较差异有统计学意义(P<0.01),其余指标差异无统计学意义。结论染色体多态性患者辅助生殖技术助孕后妊娠结局与普通人群相比未见明显差异。

Objective To explore the effects of chromosome polymorphism on the pregnancy outcome of assistant reproductive treatment. Methods The peripheral blood chromosome detection was conducted for 5 345 infertile couples who underwent the assistant reproductive treatment. The process of assistant reproduction of 3 435 periods was retrospectively analyzed. Patients with chromosome polymorphism were selected, divided into groups according to different types, and then compared to normal people. The fertilization rates, cleavage rates, rates of effective embryo formation, accumulated pregnancy rates, and early abortion rates were observed. Results Compared to the control group, the differences of fertilization rates, cleavage rates, rates of effective embryo formation, accumulated pregnancy rates, and early abortion rates of the polymorphism group, Y chromosome variation group, 1/9/16 variation group, and D/G variation group were not statistically significant （P 〉 0.05 ）, but the difference of cleavage rates of pericentric inversion of chromosome 9 was statistically significant （P 〈 0.01）. The differences of all other indexes were not statistically significant. Conclusion The pregnancy outcome of patients with chromosome polymorphism is not significantly different from normal people after the assistant reproductive treatment.