5%那他霉素联合0.2%氟康唑治疗真菌性角膜炎疗效观察

Clinical observation of the curative effect of fungal corneal ulcer treated by 5% natamycin combined with 0.2% fluconazole

目的探讨5%那他霉素联合0.2%氟康唑治疗真菌性角膜炎的临床疗效。方法真菌性角膜炎患者45例(45只眼)按照患者角膜炎侵润程度的不同将其分为非严重的中轻度组(A组)和严重的重度组(B组),两组患者均给予5%那他霉素联合0.2%氟康唑治疗,对比分析两组疗效。结果 A组总有效率为100.00%明显高于B组的57.14%(χ2=54.7771,P=0.0000);A组发病至诊治时间为(16.5±6.9)d明显短于B组的(29.8±8.7)d(P<0.05);A组经治疗后视力改善明显优于B组(P<0.05),差异均有统计学意义。结论 5%那他霉素联合0.2%氟康唑治疗真菌性角膜炎,尤其是治疗非严重的中轻度患者具有显著性效果,能有效地缩短治疗时间。

Objective To investigate the curative effect on fungal corneal ulcers treated by 5% natamycin combined with 0. 2% fluconazole. Methods Forty-five patients with fungal corneal ulcer were randomly divided into the non-severe group（ group A） and the severe group（ group B）,the two groups were treated by 5% natamycin eye drops combined with 0. 2% fluconazole,the clinical efficacy of the two groups were analyzed statistically. Results The total effective rate in group A was significantly higher than group B（ χ2= 54. 7771,P = 0. 0000）; the time of group A from pathogenesis to diagnose and treatment was significantly shorter than group B（ P〈 0. 05）; the visual improvement of group A after treatment was significantly better than group B（ P〈 0. 05）. The differences were statistically significant. Conclusion The study showed that the treatment 5% natamycin combined with 0. 2% fluconazole is remarkable effective,especially in the treatment of non-severe patients. The combined method can effectively shorten the time of treatment.