成人型色素性荨麻疹8例临床与组织病理分析

A Clinical Pathological Analysis of 8 Adult Patients with Urticaria Pigmentosa

目的提高临床医生对成人型色素性荨麻疹的临床及组织病理特点的认识。方法回顾性分析2010年3月-2012年12月中国医学科学院皮肤病研究诊治的8例成人型色素性荨麻疹患者的临床资料和组织病理学检查结果。结果皮损多表现为躯干、近端四肢圆形或类圆形的色素性斑丘疹,头面部基本不受累,掌跖部受累少见,Darier’s征均阳性,皮疹自出现后未见消退。组织病理学检查示:真皮内可见肥大细胞不同程度浸润,Giemsa染色阳性。均无皮肤以外的症状体征。结论根据典型的皮损特点及病理表现可诊断成人型色素性荨麻疹。

Objective To better characterize the clinical and histopathological findings of urticaria pigmentosa in adult. Methods The clinical presentation, histopathological findings of 8 patients presenting in Institute of Dermatology of Chinese Academy of Medical Sciences from March 2010 to December 2012 were reviewed retrospectively. Results The lesions of urticaria pigmentosa in adults were reddish-brown macules and papules that measure a centimeter or less in diameter. These lesions are most numerous on the trunk and proximal extremities and appear less frequently on the face, distal extremities or palms and soles. Darier＇ s sign was positive. Skin biopsy revealed moderate infiltration of mast cells in the upper dermis, and Giemsa stain of those cells were positive. 8 patients had no extra-cutaneous symptoms. Conclusion The dignosis of the eight cases of adult urticaria pigmentosa can be confirmed by clinical and pathological features.