兔下颌骨单层骨皮质缺损人工材料植入动物模型建立

Establishment of an Animal Model for Reconstruction of Mandibular Single Layer of Cortical Bone Defect in Rabbits.

目的:建立兔下颌骨单层骨皮质缺损人工材料植入的实验动物模型。方法:选取24只健康成年日本大耳白兔,雌雄不限,在双侧下颌骨体部形成大小为13mm×4mm×2mm的矩形单层骨皮质缺损,左侧为对照组,右侧为实验组,下颌骨植入大小为13mm×4mm×2mm的长条形碳纤维增强型聚醚醚酮(CFR/PEEK),分别于术后4、8、12周取材,影像学及组织学观察。结果:所有实验动物术后未出现感染死亡;各组实验材料未出现松动、脱落等固位不良现象,术后未出现二次骨折。结论:建立下颌骨单层骨缺损人工材料植入实验动物模型是可行的。

Objective： To establish a mandibular single layer of cortical bone defect in rabbits. Methods： Twentyfour adult Japan rabbits were used in the experiment, A rectangular single layer of cortical bone defect with the size of 13 mm×4 min×2 mm was made at both sides of the mandibular body. Implanted CFR/PEEK with the size of 13 mm × 4 mm × 2 mm at the right side as experimental group and no implants at the left side as the control group. Results： All rabbits were in good heath, without being infected. All experimental materials in the survived rabbits were in good retention. Conclusion： The method used to establish an animal model for reconstruction of mandibular single layer of cortical bone defect in rabbits is practicable.