Survivin蛋白在人成釉细胞瘤中的表达及意义

Expression of survivin in ameloblastoma and its clinical significance

目的:探讨survivin在成釉细胞瘤中的表达及意义。方法:采用免疫组织化学S-P法检测70例成釉细胞瘤(ameloblastoma,AB)、15例恶性AB、30例正常口腔黏膜中survivin的表达。采用SPLUS13.0软件包对数据进行统计学分析。结果:AB、恶性AB中survivin明显表达,恶性AB中阳性表达率最高,为100%,其次为AB(82.9%);正常口腔黏膜轻微表达,其阳性率为30%,各组间差异显著(P<0.05)。结论:AB中survivin高表达,且明显高于正常口腔黏膜。Survivin可能参与AB的发生与发展,AB的侵袭性增加和恶变与survivin的高表达相关。

PURPOSE： To study the expression of survivin in ameloblastoma and its clinical significance. METHODS： Immunohistochemical S-P method was used to detect the expression of survivin in clinical significance. Seventy cases of ameloblastoma （AB）, 15 cases of malignant AB and 30 cases of normal oral mucosa were included. SPLUS13.0 software package was used for statistical analysis. RESULTS： Survivin was strongly expressed in AB and malignant AB.. The positive rate in malignant AB was up to 100%, followed by 82.9% in AB. Survivin was weakly expressed in normal oral mucosa, with a positive rate of 30%. The difference among the 3 groups was significant （P〈0.05）. CONCLUSIONS： Survivin is overexpressed in AB compared to normal oral mucosa. Survivin is involved in the development and progress of AB, and the ability of invasion and canceration of AB is correlated with the overexpression of survivin.