摘要
对半夏厚朴汤的抗抑郁作用进行初步的研究。采用慢性束缚应激刺激对大鼠进行抑郁造模;并通过大鼠强迫游泳、悬尾、糖水偏好等行为学实验测试,评价半夏厚朴汤的抗抑郁作用。实验结果知,半夏厚朴汤200、500 mg/kg能显著缩短大鼠强迫游泳、悬尾不动时间,同时也显著提高大鼠糖水偏好率。因此,半夏厚朴汤具有显著的抗抑郁作用。
To evaluate the antidepressant effect Banxia-houpu Decoction on a preliminary study.A model of chronic restraint stress on depression rats was applied,with such behavioral tests of forced swimming test,tail suspension test and sucrose preference test to evaluate the antidepressant-like effect of Banxia-houpu decoction.From the results,Banxia-houpu Decoction at the dosage of 200,500 mg/kg in rats can significantly shorten the immobility time of forced swim test and tail suspension test,also significantly increased the rate of sucrose preference in rats.Therefore,Banxia-houpu Decoction has a significant antidepressant-like effect.
出处
《科学技术与工程》
北大核心
2014年第24期191-194,共4页
Science Technology and Engineering
基金
国家自然科学基金(21375147
81072613)
北京自然科学基金(7142125)
十二五国家科技重大专项"重大新药创制"综合性新药研究开发技术大平台(2012ZX09301003-001-010)资助
关键词
半夏厚朴汤
抗抑郁
慢性束缚应激刺激
行为学实验
Banxia-houpu Decoction
antidepressant
chronic restraint stress
behavioral tests
