沙参祛痰润燥颗粒治疗吸烟者气道炎症反应60例

Shashenqutanrunzao Granule Improving Respiratory Tract Inflammation of Long-Term Smoking for 60 cases

目的观察沙参祛痰润燥颗粒减轻长期吸烟者气道炎症反应的临床疗效。方法对60例长期吸烟者口服沙参祛痰润燥颗粒。疗程为3个月,观察测定痰液细胞分类及痰液上清液中IL-8、TNF-a浓度的变化。结果治疗后吸烟者痰液中中性粒细胞及痰液上清液IL-8浓度均有明显降低,与治疗前比较有统计学意义(P<0.05)。结论中药沙参祛痰润燥颗粒在减轻长期吸烟者气道炎症反应方面有较好的效果,值得进一步研究。

Objective To evaluate the effects on Shashenqutanrunzao Granule improving respiratory tract inflammation of long-term smoking. Methods 60 long-term smokers were were chosen and treated with Shashenqutanrunzao Granule for three months. The sputum samples were collected by inducing method before and after treatment.CeUs in the sputum were examined by microscopy.The levels of intedeukin-8 and tumor necrosis factor-tx in fluid-phase of sputum were determined by enzyme-linked Lrnmunosorbent assay （ELISA）. Results The levels of neutrophil proportion and intedeukin-8 in the sputum after treatment were compared with those before treat- ment..As for the levels of tumor necrosis factor-or no significant diference was seen before and after treatment （P 〈0.05） .Conclusion Shashenqutanrunzao Granule is an effective medicine for improving respiratory tract inflammation of long-term smoking.