血三七水煎液对局灶性脑缺血大鼠血液流变学的影响

Effect of Polygonum amplexicaule var.sinense water decoction on hemorheology in rats after focal cerebral ischemia

目的观察血三七水煎液对局灶性脑缺血大鼠血液流变学的影响。方法除对照组外,其余大鼠均采用结扎颈外动脉建立大鼠大脑中动脉局灶性脑缺血模型,造模成功的大鼠随机分为模型组,假手术组,血三七水煎液高、中、低剂量(15、10、5 g/kg)组和脑心通胶囊组(0.5 g/kg),1次/d,给药21 d后取血,测定全血黏度、全血还原黏度、红细胞聚集指数、红细胞变形指数、红细胞刚性指数和红细胞电泳指数等血液流变学指标。结果与模型组比较,各给药组的全血黏度、全血还原黏度、红细胞聚集指数、红细胞变形指数、红细胞刚性指数和红细胞电泳指数均不同程度地降低,且血三七水煎液高、中剂量组的作用效果与脑心通胶囊组相当。结论血三七水煎液可以改善局灶性脑缺血大鼠血液流变学的相关指标。

Objective To observe the effects ofPolygonum amplexicaule var. sinense water decoction （PAWD） on hemorheology in rats after focal cerebral ischemia. Methods Except the control group, all the rats in the other groups were performed to induce the middle cerebral artery occlusion model via ligation of external carotid artery. All the model rats were randomly divided into model, Sham, high-, mid-, and low-dose （15, 10, and 5 g/kg） PAWD, and Naoxintong Capsule （0.5 g/kg） groups, and administered once a day. The blood samples were taken after 21 d administration, and the whole blood viscosity, reductive viscosity, red cell assembling index, erythrocyte deformation index, erythrocyet index of rigidity, and erythrocyte electrophoresis index were determined. Results Compared with the model group, the whole blood viscosity, reductive viscosity, red cell assembling index, erythrocyte deformation index, erythrocyet index of rigidity, and erythrocyte electrophoresis index in each treatment group had descended to some extent. The pharmacological actions of high- and mid-dose PAWD groups were equal to those of Naoxintong Capsule group. Conclusion PAWD could improve the hemorheology in rats after focal cerebral ischemia, which is worthy of research and development.