咳喘膏穴位贴敷对哮喘豚鼠嗜酸细胞趋化因子和组胺的影响

Effect of Kechuangao acupoint application on eotaxin and histamine in asthma guinea pigs

目的观察咳喘膏对哮喘豚鼠嗜酸细胞趋化因子、组胺的影响,探讨其作用机制。方法将豚鼠随机分为对照组,模型组,地塞米松组,咳喘膏穴位贴药1、3、6 h组,每组各10例。卵蛋白致敏并诱发哮喘,行穴位贴敷。检测各组嗜酸性粒细胞趋化因子、血组胺水平。结果咳喘膏穴位贴敷各组嗜酸性粒细胞趋化因子、组胺较模型明显减低。结论咳喘膏穴位贴敷可改善豚鼠哮喘气道炎性反应。

Objective To observe the effect of Kechuangao acupoint application on the changes of eotaxin and histamine in asthma guinea pigs and to explore its underlying mechanism. Methods Guinea pigs were randomly divided into normal control group, model group, Dexamethasone group, and Kechuangao acupoint application 1, 3, and 6 h groups. Each group had 10 animals. Asthma model was established by ip injection of ovalbumin and forced inhalation. External application was made on guinea pigs back. Levels of eotaxin and histamine were detected after course of treatment. Results Compared with model group, the levels of eotaxin and histamine decreased significantly in t Kechuangao acupoint application groups, and bettered than others. Conclusion Kechuangao acupoint application can relieve the phlegmonosis injuries in pulmonary tissue of asthma guinea pigs, which may contribute to its therapeutic effect in relieving asthma.