圣曲红曲胶囊治疗血脂异常的疗程确定及疗效观察

Clinical observation and treatment course determination of Shengqu Hongqu Capsules in treatment of dyslipidemia

目的研究圣曲红曲胶囊治疗血脂异常的疗程确定及疗效。方法将120例血脂异常患者随机分为圣曲红曲胶囊连续治疗、非连续治疗组和对照组,每组40例。圣曲红曲胶囊连续治疗组服用圣曲红曲胶囊2粒/次,3次/d,连续服用12周;圣曲红曲胶囊非连续治疗组服用圣曲红曲胶囊2粒/次,3次/d,连续服用8周,停药4周;对照组服用辛伐他汀片10 mg/d,连续服用8周。3组分别于治疗前、治疗8周后测量血脂,圣曲红曲胶囊连续治疗、非连续治疗组于治疗12周后再测量一次血脂数据。结果治疗8周后,与对照组比较,圣曲红曲胶囊连续治疗、非连续治疗组的总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)均降低,但差异均无统计学意义;与对照组比较,圣曲红曲胶囊连续治疗组的高密度脂蛋白胆固醇(HDL-C)升高,且差异有统计学意义(P<0.05);圣曲红曲胶囊非连续治疗组的HDL-C无显著变化。治疗12周后,与圣曲红曲胶囊非连续治疗组比较,圣曲红曲胶囊连续治疗组TC、TG、LDL-C均显著降低,HDL-C显著升高(P<0.05)。结论圣曲红曲胶囊治疗血脂异常比辛伐他汀具有明显的优势,且为了取得长期、稳定的降脂效果,必须以3个月为一疗程,坚持服用。

Objective To study the clinical efficacy and treatment course determination of Shengqu Hongqu Capsules in treatment of dyslipidemia. Methods Dyslipidemia patients （120 cases） were randomly divided into Shengqu Hongqu Capsules continuous treatment group, Shengqu Hongqu Capsules noncontinuous treatment group, and control group. Each group had 40 cases. The patients in the Shengqu Hongqu Capsules continuous treatment group were given Shengqu Hongqu Capsules three grains/time, three times daily. They were treated continuously for 12 weeks. The patients in the Shengqu Hongqu Capsules noncontinuous treatment group were given Shengqu Hongqu Capsules three grains/time, three times daily. They were treated continuously for 8 weeks, and were stopped for 4 weeks. The patients in the control group werepo administered with Simvastatin Tablets 10 mg/d for 8 weeks. Lipid data of three groups were tested before treatment and 8 weeks after the treatment. Lipid data of the Shengqu Hongqu Capsules continuous treatment group and Shengqu Hongqu Capsules noncontinuous treatment group were tested again 12 weeks after the treatment. Results Eight weeks after the treatment, compared with the control group, total cholesterol （TC）, triglycerides （TG）, low density lipoprotein （LDL-C） in the Shengqu Hongqu Capsules continuous treatment group and Shengqu Hongqu Capsules noncontinuous treatment group were decreased, but there was no significant difference. Compared with the control group, high density lipoprotein （HDL-C） in the Shengqu Hongqu Capsules continuous treatment group increased with significant difference （P 〈 0.05）; that in Shengqu Hongqu Capsules noncontinuous treatment group did not change significantly. Twelve weeks after the treatment, compared with noncontinuous treatment group, TC, TG and LDL-C in Shengqu Hongqu Capsules continuous treatment group decreased withsignificant difference. HDL-C in the Shengqu Hongqu Capsules continuous treatment group increased with significant difference （P 〈 0.05）. Conclusion Compared with Simvastatin, Shengqu Hongqu Capsules have the significant advantages. And to get the long and stable lipid-lowering effect, Shengqu Hongqu Capsules should be administered continuously, and 3 months will be a course.