阿拉瑞林预防卵巢子宫内膜异位囊肿术后复发的疗效观察

Observation on clinical efficacy of alareilin in preventing recurrence of ovarian endometriosis cyst after operation

目的探讨阿拉瑞林预防卵巢子宫内膜异位囊肿术后复发的临床疗效。方法回顾性收集2008年3月—2010年12月天津市美中宜和妇儿医院收治的卵巢子宫内膜异位囊肿(OEC)患者54例为研究对象,行腹腔镜下囊肿剔除术,并于术后第1次月经的第一天给予注射用阿拉瑞林150μg/d,肌肉注射,连续5 d,每4周为1个周期,连续6个周期。以同期单纯腹腔镜下囊肿剔除术的OEC患者50例为对照。通过查阅病史,比较两组患者的临床疗效、复发时间、累积复发率和累积生存率。结果治疗组和对照组的总有效率分别为92.59%、78.00%,两组比较差异有统计学意义(P<0.05)。治疗组平均复发时间(24.69±3.69)个月,对照组为(18.65±1.25)个月,两组复发时间比较差异具有统计学意义(P<0.01);治疗组患者累积复发率均明显低于对照组,累积生存率明显高于对照组,两组比较差异具有统计学意义(P<0.01)。结论阿拉瑞林能够提高OEC患者腹腔镜下囊肿剔除术的临床疗效,延长复发时间,减少复发率,具有重要的预防价值。

Objective To investigate the clinical efficacy of alareilin in preventing the recurrence of ovarian endometriosis cyst （OEC） after the operation. Methods Retrospectively collected 54 patients with OEC in Tianjin Meizhong Yihe Women and Children＇s Hospital from March 2008 to December 2010 as the research object. The patients were accepted the operation of laparoscopic cyst removed, and they were im administered with alareilin 150 μg/d on day 1 of the first menstruation after the operation, and lasted for 5 d. Every 4 week was as one cycle, and they were continuously treated for six cycles. Fifty patients with OEC, who were accepted pure operation of laparoscopic cyst removed in the same period, were as control. Clinical efficacy, recurrence time, accumulated recurrence rate, and cumulative survival rate were compared by referring to the history. Results The total effective rates of the patients in the treatment and control groups were 92.59% and 78.00%, respectively, with the significant difference between the two groups （P 〈 0.05）. The average recurrence time of the patients in the treatment group was （24.69 ± 3.69） months, and that of the patients in the control group was （18.65 ± 1.25） months, with the significant difference between the two groups （P 〈 0.01）. Cumulative recurrence rate of the patients in treatment group was significantly lower than that of the patients in the control group. At the same time, the cumulative survival rate was significantly higher than that in the control group, with the significant difference between the two groups （P 〈 0.01）. Conclusion Alareilin could improve the clinical curative effect of patients with OEC undergoing laparoscopic cyst, and prolong the time of recurrence, reduce the recurrence rate, which has the important value of prevention on recurrence of OEC.