新疆维吾尔族和汉族女性乳腺癌临床病理学参数比较及分析

Comparison of clinicopathological information between Uyghur and Han female patients with breast cancer

目的探讨维吾尔族和汉族女性乳腺癌患者临床病理学参数的差异性。方法在新疆医科大学第一附属医院病理科医院信息系统(HIS)中检索2008年1月-2014年1月储存的维吾尔族及汉族女性原发性乳腺癌患者的临床病理信息,按临床病理学参数归类,运用统计学方法进行回顾性对比分析。结果共收集符合条件的女性乳腺癌患者1 366例,其中维吾尔族294例,汉族1 072例,维、汉族女性乳腺癌患者人数之比约为1∶4。与汉族患者相比,维吾尔族患者的发病年龄年轻化,临床分期较晚,恶性程度较高,淋巴结转移数目偏多,表皮生长因子受体2(Her-2)阳性表达患者较多,差异均具有统计学意义(P<0.05)。维、汉族乳腺癌患者的临床病理类型均以浸润性非特殊癌为主,并且维吾尔族女性孕激素受体(PR)阴性表达者居多,差异均有统计学意义(P<0.05),雌激素受体(ER)的表达无明显差异(P>0.05)。结论对年龄<35岁维吾尔女性患者进行早期乳腺肿块定期普查或早期筛查并做到早诊早治,具有重要的肿瘤预防意义;维吾尔族女性乳腺癌患者治疗模式与汉族女性乳腺癌患者显著不同,临床靶向治疗应当区别对待。

Objective To compare the clinicopathological information of female breast cancer patients be-tween Uyghur and Han.Methods The clinicopathological information was retrieved and retrospectively analyzed from January 2008 to January 2014 between Uyghur and Han female patients with breast cancer in the department of pathology,the First Affiliated Hospital of Xinjiang Medical University.The data were analyzed by statistical methods using SPSS 17.0 version software.Results There were 1 366 cases of breast cancer patients were retrieved and recruited,of whom there were 294 Uyghur female patients and 1 072 Han female patients.The ratio of Uyghur to Han is about 1∶4.Compared with Han patients,there was a significant difference in age of disease,clinical stage,lymph node metastasis and human epidermal growth factor receptor 2 （Her-2）positive expression （P 〈0.05）in Uyghur female patients.The chief his-topathological subtypes of the two ethnic groups were nonspecific invasive carcinoma （P〈0.05）,and pro-gesterone receptor （PR）expression was significantly different between Han and Uyghur patients （P 〈0.05）,but there was no significant difference of estrogen receptor （ER）expression between Han and Uy-ghur patients.Conclusion There would be much prophylactic significance of early examination for breast cancer in Uyghur female patients with breast lesion whose ages were below 35 years;given the different ex-pression of Her-2 and PR between Han and Uyghur female patients,clinical therapy should be made differently.