Beclin-1在肾小球足细胞自噬调控中的作用

Role of Becliu-1 in the autophagic regulation of podocyte

自噬是一个发生在真核细胞中由细胞初级溶酶体处理内源性底物的一系列生化过程，其主要作用是清除和降解自身受损的细胞器及多余的生物大分子，并利用降解产物提供能量和重建细胞结构，在维持细胞稳态和细胞生命活动等方面起重要作用。近年来，研究发现肾小球足细胞的自噬活性水平与足细胞的损伤和蛋白尿的发生发展有关。自噬在肾小球足细胞中起到的调控作用成为对抗足细胞损伤的研究热点，其中自噬相关基因Beclin—1在自噬调控中的作用更是引起了广泛关注。现就近年来关于Beclin-1在足细胞自噬调控中作用的相关研究进行综述。

Autophagy is the cytoplasm and organelles of eukaryotic cells through degradation of itself, a “self digest”, a series of biochemical process is a kind of programmed cell death, its main function is to remove and degrade its damaged organelles and redundant biological macromolecules, and use the degradation products provide energy, reconstruction and cellular structure, in the steady state of cell and cell life activities play an important role. In recent years, autophagy in glomerular cells play a role of regulation and control have become the focus in the confrontation podocyte damage,including Beclin-1 autophagy related genes in the role of autophagy regulation has caused wide public concern. This article chooses of Beclin-1 in sertoli cell autophagy related research in the role of regulation are reviewed.