肺癌患者下呼吸道感染相关危险因素分析

Analysis of risk factors for patients with lung cancer complicated with lower respiratory tract infections

目的探讨肺癌患者合并下呼吸道感染时相关危险因素,并进行统计分析,以降低感染率。方法选取2010年12月-2012年12月收治的肺癌患者140例进行研究,观察患者下呼吸道感染情况,对所有患者的临床资料进行分析,探讨呼吸道感染的相关危险因素。结果 140例肺癌患者发生呼吸道感染85例,感染率为60.71%;对患者临床资料进行单因素分析发现,年龄、吸烟、基础疾病≥3种、肺癌分期、住院时间、化疗和大剂量使用抗菌药物是发生下呼吸道感染的危险因素(P<0.05);经多因素logistic回归分析发现,年龄、基础疾病≥3种、住院时间、肺癌分期及大剂量长期使用抗菌药物是导致肺癌患者发生下呼吸道感染的独立危险因素。结论导致肺癌患者发生下呼吸道感染的因素较多,临床需要对高龄糖尿病及肺癌晚期患者进行密切观察,严格控制抗菌药物的滥用,防止下呼吸道感染的发生。

OBJECTIVE To study the risk factors for patients with lung cancer complicated with lower respiratory tract infections ,and conduct statistical analysis to reduce the infection rate .METHODS Totally 140 patients with lung cancer from Dec .2010 to Dec .2012 in our hospital were studied .The situation of lower respiratory tract infection was observed .The clinical data for all patients were analyzed to explore the relevant risk factors of respiratory tract infections . RESULTS Totally 85 out of 140 patients with lung cancer had respiratory tract infections ,the rate was 60 .71% .The univariate analysis of clinical data of patients showed that the patient＆#39;s age , smoking ,underlying diseases ≥ 3 kinds ,lung cancer staging ,length of stay ,chemotherapy and the use of high-dose antibiotics were risk factors for lower respiratory tract infections in patients with lung cancer （P〈0 .05） . The multivariate logistic regression analysis found that age ,underlying diseases ≥ 3 kinds ,hospitalization time , lung cancer staging and long-term use of high doses of antibiotics were independent risk factors for lower respirato-ry tract infection in patients with lung cancer .CONCLUSIONS There are various factors related to lower respirato-ry tract infection in patients with lung cancer .The clinicians should perform close observation for patients with elderly diabetes and late staged lung cancer and strictly control the abuse of antibiotics to prevent lower respiratory tract infections .