盐酸溴己新葡萄糖注射液治疗下呼吸道感染患儿的临床研究

Clinical study on bromhexine hydrochloride and glucose injection for treatment of children with lower respiratory tract infections

目的探讨盐酸溴己新葡萄糖注射液治疗下呼吸道感染患儿的临床效果,以期提高临床诊治水平。方法随机选取2011年1月-2013年1月90例下呼吸道感染患儿为研究对象,随机分成两组,各45例,对照组予以常规综合治疗,观察组在对照组基础上加用盐酸溴己新葡萄糖注射液治疗,对比分析两组临床疗效。结果两组在住院时间、咳嗽、咳痰液、喘息、气促、紫绀、肺部哮鸣音、肺部湿啰音方面比较差异有统计学意义(P<0.05);对照组的治愈率为37.78%、总有效率为75.56%;观察组治愈率62.22%、总有效率为91.11%;肺功能:对照组一秒用力呼气容积(FEV1)、峰值呼气流速(PEF)显效率为28.89%、35.56%,总有效率分别为80.00%、77.78%,观察组FEV1、PEF显效率为64.44%、68.89%,总有效率分别为91.11%、93.33%,两组比较差异有统计学意义(P<0.05)。结论盐酸溴己新葡萄糖注射液有助于提高下呼吸道感染患儿临床效果、缩短住院时间、减轻临床症状。

OBJECTIVE To investigate the efficacy of bromhexine hydrochloride and glucose injection for treatment of children with lower respiratory tract infections , in order to improve the clinical diagnosis and therapy . METHODS Totally 90 children with lower respiratory tract infections in Jan .2011-Jan .2013 were randomly se-lected as the study subjects and were divided into two groups with 45 children in each .The control group received conventional treatment ,while the observation group received bromhexine hydrochloride and glucose injection based on conventional treatment ,clinical effects were observed after treatment .RESULTS There were significant differ-ences in duration of hospitalization ,cough ,sputum ,wheezing ,shortness of breath ,cyanosis ,wheezing lungs , lung auscultation between the two groups （P＆lt;0 .05） .The cure rate was 37 .78% ,and the total effective rate was 75 .56% in the control group;the cure rate was 62 .22% ,and the total effective rate was 91 .11% in the observa-tion group .For lung function ,the forced expiratory volume in one second （FEV1） ,and the peak expiratory flow （PEF） effective rate was 28 .89% ,35 .56% in the control group ,the total effective rate was 80% ,77 .78% ,com-pared to 64 .44% ,68 .89% in the observation group with the total effective rate of 91 .11% ,93 .34% ,the differ-ence was significant （P＆lt;0 .05） .CONCLUSION Bromhexine hydrochloride and glucose injection helps to improve clinical outcomes in children with lower respiratory tract infection ,shorten hospital stays ,and alleviate clinical symptoms .