摘要
目的评价人附睾分泌蛋白4(HE4)ELISA试剂盒与CA125联合诊断卵巢癌的意义;方法两种(HE4)ELISA法检测上皮性卵巢癌114例。对照组为盆腔包块疑似样本59例,其他妇科良性疾病30例,肺癌、结直肠癌及乳腺癌患者45例,孕妇血清30例,正常人血清100例。实验组检测CA125。结果 HE4_义翘和HE4_康乃格试剂盒诊断卵巢癌敏感性为74.6%和70.2%,联合CA125诊断敏感性为73.2%和68.8%;在早期和晚期卵巢癌的诊断中,HE4_义翘试剂盒敏感性为66.7%和79%,HE4_康乃格试剂盒敏感性为48.1%和79%;HE4_义翘联合CA125敏感性为66.7%和77.2%,HE4_康乃格联合CA125敏感性为48%和77.2%。两试剂盒在各组数据中有强的相关性,相关系数为0.963。结论 HE4_义翘试剂盒在早期诊断卵巢癌方面较好。
Objective To evaluate the value of domestic human epididymis protein 4 （HFA） ELISA kit com- bined with CA125 in the diagnosis of ovarian carcinoma. Methods HE4 was detected by using HE4 _ Y and HE4 _ K Kits in 114 cases of epithelial ovarian carcinoma, The control group was consisted with 59 cases of pelvic masssuspected samples, 30 patients with other benign gynecological disease, 45cases of lung cancer, colon cancer or breast cancer, 30 cases of pregnant women, 100 cases of normal human serum. CA125 level was detected simultaneously. Results The sensitivity of HE4 _ Y and HFA _ K kit for diagnosis of ovarian cancer was 74. 6o/oo and 70.2%, combined with CA12s, it was 73.2% and 68. 8%; for the diagnosis of early and late ovarian carcinoma, sensitivity of HE4 _ Y kit was 66.7% and 79%, and HE4 _ K kit was 48.1% and 79%; the sensitivity of HE4 _ Y combined with CA125 was 66.7% and 77.2% and was 48% and 77.2% in the combination of HE4 _ K and CA12s. Sensitivity of HE4 _ Y and HE4 _ K kit had strong correlation in each group, the correlation coefficient was 0. 963. Conclusion FA _ Y kit is better than HE4 _ K kit in the early diagnosis of ovarian cancer.
出处
《中国妇产科临床杂志》
2014年第5期395-397,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
国家高技术发展计划(863计划
2012AA02A507)
