血清胸苷激酶1水平与鼻咽癌临床病理特征的关系

Correlation of serum thymidine kinase-1 and pathological characteristics of nasopharyngeal carcinoma

目的探讨鼻咽癌患者血清中胸苷激酶1(TK-1)的表达水平与临床病理特征之间的关系。方法选择2010年5月至2013年3月收治的58例鼻咽癌患者(试验组)和40例健康人(对照组),采用免疫印迹增强化学发光法检测血清中TK-1的浓度。结果试验组患者治疗前的血清TK-1水平显著高于对照组,差异有统计学意义(P<0.05)。治疗后,试验组患者的血清TK-1水平显著低于治疗前,差异有统计学意义(P<0.05)。试验组患者治疗前的血清TK-1水平随着TNM分期的升高呈现上升趋势,Ⅲ期和Ⅳ期患者的血清TK-1水平稍高于Ⅰ期和Ⅱ期,差异无统计学意义(P>0.05)。治疗后,Ⅲ期和Ⅳ期患者的血清TK-1水平显著高于Ⅰ期和Ⅱ期,差异有统计学意义(P<0.05)。试验组患者治疗前后血清TK-1水平与淋巴结转移无关(P>0.05)。结论鼻咽癌患者血清TK-1高表达,血清TK-l水平不仅对鼻咽癌早期诊断具有重要临床意义,且对肿瘤治疗、预后和病情的评估也有较高的临床价值。

Objective To investigate the correlation of serum thymidine kinase-1 （TK-1） and pathological characteristics in patients with nasopharyngeal carcinoma. Methods A total of 58 patients with nasopharyngeal carcinoma （ observation group） and 40 cases of healthy subjects （ control group） were col- lected from May 2010 to March 2013. Concentrations of serum TK-1 were determined using Western blot en- hanced chemil Results The pre-therapy serum TK-1 concentration of observation group was significantly higher than that of control group （ P 〈 0. 05 ）. The post-therapy serum TK-1 of observation group was significantly lower than that of pre-therapy （ P 〈 0. 05 ）. The pre-therapy serum TK-1 levels of ob- servation group show increasing tendency along with TNM stages. The serum TK-1 levels of stage III and IV were slightly higher than those of stage I and H. The post-therapy serum TK-1 levels of stage HI and IV were significantly higher than those of stage I and II （ P 〈 0. 05 ）. There was no relationship between the pre- and post-therapy serum TK-1 levels and metastasis of lymph node. Conclusion Serum TK-1 levels in patients with nasopharyngeal carcinoma showed high expression. Serum TK-1 levels not only benefit early di- agnosis of nasopharyngeal carcinoma but also have high clinical value of therapy, prognosis and assessment of disease.